Breast cancer pathology, receptor status, and patterns of metastasis in a rural Appalachian population

Details

• Personal Author:
  Abraham J ; Ducatman B ; Gadiyaram V ; Hazard H ; Hobbs G ; Kurian S ; Rose DP ; Vona-Davis L
• Description:
  Breast cancer patients in rural Appalachia have a high prevalence of obesity and poverty, together with more triple-negative phenotypes. We reviewed clinical records for tumor receptor status and time to distant metastasis. Body mass index, tumor size, grade, nodal status, and receptor status were related to metastatic patterns. For 687 patients, 13.8% developed metastases to bone (n = 42) or visceral sites (n = 53). Metastases to viscera occurred within five years, a latent period which was shorter than that for bone (P = 0.042).More women with visceral metastasis presented with grade 3 tumors compared with the bone and non metastatic groups (P = 0.0002). There were 135/574 women (23.5%) with triple-negative breast cancer, who presented with lymph node involvement and visceral metastases (68.2% versus 24.3%; P = 0.033). Triple-negative tumors that metastasized to visceral sites were larger (P = 0.007). Developing a visceral metastasis within 10 years was higher among women with triple-negative tumors. Across all breast cancer receptor subtypes, the probability of remaining distant metastasis-free was greater for brain and liver than for lung. The excess risk of metastatic spread to visceral organs in triple-negative breast cancers, even in the absence of positive nodes, was combined with the burden of larger and more advanced tumors. [Description provided by NIOSH]
• Subjects:
  Demography Lymphatic System Men Neoplasms Occupational Health Pathology Safety Women
• Keywords:
  BMI Body Mass Index Bone Cancer Bone Disorders Breast Cancer Cancer Demographic Characteristics Humans Lymph Nodes Metastases Obesity Sociological Factors Tumors

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• ISSN:
  1687-8566
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  2014
• NIOSHTIC Number:
  nn:20049498
• Citation:
  J Cancer Epidemiol 2014 Jan; 2014:170634
• Contact Point Address:
  Linda Vona-Davis, Department of Surgery, Mary Babb Randolph Cancer Center, Robert C. Byrd Health Sciences Center,West Virginia University, P.O. Box 9238, Morgantown,WV 26506
• Email:
  lvdavis@hsc.wvu.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Journal of Cancer Epidemiology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:db7d85897f05b20b99ba5a40f83b53ccbbc55e1a131c9c4512103d4eecf5a9edf3cb1627467f00d8416488fe1a659f3210e2b2c9975af68e0ff97c9d0005a854
• Download URL:
  https://stacks.cdc.gov/view/cdc/203938/cdc_203938_DS1.pdf
• File Type:
  [PDF - 1.40 MB ]