Association between birth characteristics and coronary disease risk factors among fifth graders

Details

• Personal Author:
  Cottrell L ; Dong L ; Gadikota K ; Hobbs G ; Lilly C ; Mullett MD ; Neal WA
• Description:
  OBJECTIVE: To evaluate the associations between selected birth characteristics-prematurity and poor intrauterine growth-and risk factors for coronary artery disease detected among children enrolled in the fifth grade. STUDY DESIGN: Children (n = 3054) with matched birth and fifth grade health screening data on body mass index (BMI), systolic blood pressure, and fasting lipid profiles were analyzed using MANOVA with the following independent variables of weight gain by the fifth grade: BMI percentile, normal or overweight/obese (BMI > 85 th percentile), prematurity, and intrauterine growth (ie, small for gestational age [SGA], appropriate for gestational age [AGA], or large for gestational age [LGA]). RESULTS: LGA status at birth was associated with overweight/obesity later in life. In fifth grade, overweight/obese children had elevated systolic blood pressure and abnormal levels of most fasting serum lipids compared with normal-weight children regardless of birth characteristics. Beyond the effects of BMI percentile, preterm infants had higher levels of triglycerides (TG) than term infants by the fifth grade (P < .05). SGA infants who become overweight/obese had higher levels of TGs and very low-density lipoproteins compared with AGA and LGA infants, whether overweight or normal weight (P < .05). CONCLUSION: BMI >85 th percentile in the fifth grade is associated with abnormalities in most coronary artery risk factors regardless of birth characteristics. Beyond the effects of BMI percentile in the fifth grade, preterm infants had higher TG levels than term infants. SGA infants who were overweight/obese in the fifth grade had higher TG and very low-density lipoprotein levels compared with AGA and LGA infants who were overweight/obese or of normal weight in the fifth grade. [Description provided by NIOSH]
• Subjects:
  Blood Cardiovascular Diseases Cardiovascular System Epidemiology Lipids Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Blood Pressure BMI Body Mass Index Cardiac Function Cardiovascular System Cardiovascular System Disease Cardiovascular System Disorders Children Diseases Heart Disease Obesity Physiopathology Risk Factors Systolic Pressure Weight Factors Weight Measurement

  More +
• ISSN:
  0022-3476
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  78-82
• Volume:
  164
• Issue:
  1
• NIOSHTIC Number:
  nn:20049497
• Citation:
  J Pediatr 2014 Jan; 164(1):78-82
• Contact Point Address:
  Martha D. Mullett, MD, MPH, Department of Pediatrics, PO Box 9214, Robert C. Byrd Health Sciences Center, Morgantown, WV 26506-9214
• Email:
  mmullett@hsc.wvu.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  The Journal of Pediatrics
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:368f748934c01bd782b5425054c1f31805a48c431de04edb8bc4d61b682ab13b2070a7fef50f8183b50210517a3cac713095c086e6eebc735dc6135b741a0a01
• Download URL:
  https://stacks.cdc.gov/view/cdc/203937/cdc_203937_DS1.pdf
• File Type:
  [PDF - 128.41 KB ]