Evaluation of extended interval dosing aminoglycosides in the morbidly obese population

Details

• Personal Author:
  Cumpston A ; Hobbs GR ; McKnight R ; Ross AL ; Tharp JL ; Cumpston A ; Hobbs GR ; McKnight R ; Ross AL ; Tharp JL
• Description:
  Aminoglycoside dosing has been studied in the obese population, typically recommending an adjusted weight utilizing a 40% dosing weight correction factor (IBW + 0.4 × (TBW-IBW)). These studies included limited numbers of morbidly obese patients and were not done in the era of extended interval aminoglycoside dosing. Here, we report a retrospective evaluation of morbidly obese patients receiving gentamicin or tobramycin at our hospital. The objective of this study was to evaluate the accuracy of the commonly recommended adjusted weight for weight-based dosing. There were 31 morbidly obese patients who received gentamicin or tobramycin 5-7?mg/kg every 24 hours using a 40% dosing weight correction factor. Our institution utilizes 16-hour postdose concentrations to monitor extended interval aminoglycosides. Twenty-two of the 31 patients (71%) achieved an appropriate serum drug concentration. Four patients (13%) were found to be supratherapeutic and 5 patients (16%) subtherapeutic. The only variable that correlated with supratherapeutic levels was older age (P = 0.0378). Our study helps to validate the current dosing weight correction factor (40%) in the morbidly obese population. We recommend caution when dosing aminoglycosides in morbidly obese patients who are of older age. [Description provided by NIOSH]
• Subjects:
  Cardiovascular System Energy Metabolism Men Occupational Health Safety Women
• Keywords:
  Absorption Cardiac Function Humans Metabolism Obesity Pharmacology Proteins Weight Factors Weight Measurement
• ISSN:
  1687-6334
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Kentucky ; OSHA Region 3 ; OSHA Region 4 ; Tennessee ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  2013
• NIOSHTIC Number:
  nn:20049496
• Citation:
  Adv Pharmacol Sci 2013 Aug; 2013:194389
• Contact Point Address:
  Aaron Cumpston, Department of Pharmacy,West Virginia University Healthcare, 1 Medical Center Drive, Morgantown,WV 26506
• Email:
  cumpstona@wvuhealthcare.com
• Federal Fiscal Year:
  2013
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Advances in Pharmacological Sciences
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c29b1ec728de7e71ea816ae693ad8e8f991b78acbf155e88089df0e29cc4c07620ee13ed21627f1d9e69e93daa34ad5ec424196eaafd00ed48129c8beb1ed5b4
• Download URL:
  https://stacks.cdc.gov/view/cdc/203936/cdc_203936_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]