Predicted vs. measured Vo(2) peak in overweight and obese hormone-negative breast cancer survivors

Details

• Personal Author:
  Abraham J ; Bonner D ; Garcia J ; Gilleland D ; Hobbs H ; Kurian S ; Reynolds A ; Swisher A ; Vona-Davis L ; Watts B ; Yanosik MA
• Description:
  PURPOSE: Obesity and physical inactivity have been linked to higher risk of developing breast cancer as well as poorer outcomes of treatment. These risks may be especially high for women with hormone-receptor negative cancers. Unlike other forms of cancer, breast cancer treatment often leads to weight gain, thus weight management is a critical issue for survivors. We developed a program, Get Fit for the Fight that aims to reduce obesity through adoption of regular physical activity and healthy eating behaviors. One outcome of the program is maximal aerobic capacity. The purpose of this study was to determine the relationship between predicted and measured peak oxygen consumption (VO2peak) in overweight and obese breast cancer survivors. METHODS: To date, 23 women (mean age 53.6 yrs) who were at least 12 months after completion of treatment for hormone-receptor negative breast cancer with a BMI > 25 (mean 31.3 kg/m2) have been enrolled into the study. At baseline, all women underwent full cardiopulmonary exercise testing to volitional maximal levels using a modified Balke treadmill protocol with measured expired gas analysis. Measured VO2peak was compared to VO2peak predicted from standard equations utilizing treadmill speed and grade. A t-test was performed to determine difference and significance was set at p < 0.05. RESULTS: At baseline, mean measured VO2 peak was 19.9 ml/kg/min (SD = 4.9), which was significantly (p<0.01) higher than predicted values (mean 16.7 ml/kg/min; SD = 1.7). Measured VO2peak values were higher than predicted in 19 of 23 subjects (83%). Mean exercise time on the test was 13.2 min (SD = 3.3 min). Mean maximal respiratory exchange ratio (RER) was 1.05 (SD = 0.7) and mean maximal heart rate was 163 beats/min (SD = 24.5), both of which were indicators of maximal effort on the test. CONCLUSIONS: Predicting VO2peak from peak workload on a treadmill test significantly underestimates measured VO2 peak in overweight/obese survivors of triple-negative breast cancer. This lack of agreement may reflect changes in exercise metabolism due to either breast cancer or its treatment. Measured, not predicted, values should be used in this population. Funding: WV EPSCoR # EPS08-07; Oncology Section, American Physical Therapy Association Clinical Trial Registration: NCT01498536 [Description provided by NIOSH]
• Subjects:
  Behavior Cardiovascular System Endocrine System Neoplasms Occupational Health Oxygen Respiratory System Risk Assessment Risk Factors Safety
• Keywords:
  Aerobic Metabolism Breast Cancer Cancer Heart Rate Hormones Obesity Oxygen Levels Physical Exercise Physical Fitness Physiological Effects Physiology Respiratory Function Respiratory Rate Risk Factors Treatment

  More +
• ISSN:
  0195-9131
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  45
• NIOSHTIC Number:
  nn:20049483
• Citation:
  Med Sci Sports Exerc 2013 May; 45(Suppl 1 5S):213
• Federal Fiscal Year:
  2013
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Medicine and Science in Sports and Exercise
• Supplement:
  1 5S
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2e53a9f537a3089c0ba604ea92f320f3e7fd003b2d12cf7c416becc34ca24896a3bc4bc9d3b58c04921866515243b18057b53e3b27ad50f2adcca9e71f83ce83
• Download URL:
  https://stacks.cdc.gov/view/cdc/203924/cdc_203924_DS1.pdf
• File Type:
  [PDF - 60.91 KB ]