Risks associated with lentiviral vector exposures and prevention strategies

Details

• Personal Author:
  Baden LR ; Byers K ; Christiani, David C. ; Diamond DV ; Duane EG ; Fujimoto G ; Gelfand JA ; Howard J ; Hudson TW ; Mostoslavsky G ; Schlimgen R ; Thompson M ; Vyas JM ; Winters T ; Wooley D ; Yang OO
• Description:
  Lentiviral vectors (LVVs) are powerful genetic tools that are being used with greater frequency in biomedical laboratories and clinical trials. Adverse events reported from initial clinical studies provide a basis for risk assessment of occupational exposures, yet many questions remain about the potential harm that LVVs may cause. We review those risks and provide a framework for principal investigators, Institutional Biosafety Committees, and occupational health professionals to assess and communicate the risks of exposure to staff. We also provide recommendations to federal research and regulatory agencies for tracking LVV exposures to evaluate long-term outcomes. U.S. Food and Drug Administration approved antiviral drugs for HIV have theoretical benefits in LVV exposures, although evidence to support their use is currently limited. If treatment is appropriate, we recommend a 7-day treatment with an integrase inhibitor with or without a reverse transcriptase inhibitor within 72 hours of exposure. [Description provided by NIOSH]
• Subjects:
  Genetics Hazardous Substances Health Promotion HIV Laboratories Neoplasms Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Viral Diseases

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• Keywords:
  Biological Materials Cell Transformation Cell Type Cellular Effects Clinical Techniques Deoxyribonucleic Acids Disease Vectors DNA Employee Exposure Gene Expression Gene Mutation Gene Regulation Genes Hazard Communication Health Communications Health Effects Health Protection Human Immunodeficiency Virus In Vitro Study In Vivo Study Medical Treatment Oncogenic Agents Risk Analysis Risk Assessment Risk Factors Risk Management Therapeutic Agents Tumors Viral Infections

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• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; District of Columbia ; Georgia ; Massachusetts ; Michigan ; OSHA Region 1 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  12
• NIOSHTIC Number:
  nn:20049015
• Citation:
  J Occup Environ Med 2016 Dec; 58(12):1159-1166
• Contact Point Address:
  Jatin M. Vyas, MD, PhD, Massachusetts General Hospital, 55 Fruit St, GRJ-5-504, Boston, MA 02114
• Email:
  jvyas@partners.org
• Federal Fiscal Year:
  2017
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0ea3fda4867915683f5edf598fd5b991fcb819479da64a5cfa770ada35a9ef77477d2297b133abba1421f98e2058b74c68b59b04b3065313747280639d08e781
• Download URL:
  https://stacks.cdc.gov/view/cdc/203611/cdc_203611_DS1.pdf
• File Type:
  [PDF - 367.92 KB ]