Hyaluronic acid-modified multifunctional Q-graphene for targeted killing of drug-resistant lung cancer cells

Details

• Personal Author:
  Cai X ; Du D ; Li H ; Lin Y ; Luo Y
• Description:
  Considering the urgent need to explore multifunctional drug delivery system for overcoming multidrug resistance, we prepared a new nanocarbon material Q-Graphene as a nanocarrier for killing drug-resistant lung cancer cells. Attributing to the introduction of hyaluronic acid and rhodamine B isothiocyanate (RBITC), the Q-Graphene-based drug delivery system was endowed with dual function of targeted drug delivery and fluorescence imaging. Additionally, doxorubicin (DOX) as a model drug was loaded on the surface of Q-Graphene via p-p stacking. Interestingly, the fluorescence of DOX was quenched by Q-Graphene due to its strong electron-accepting capability, and a significant recovery of fluorescence was observed, while DOX was released from Q-Graphene. Because of the RBITC labeling and the effect of fluorescence quenching/restoring of Q-Graphene, the uptake of nanoparticles and intracellular DOX release can be tracked. Overall, a highly promising multifunctional nanoplatform was developed for tracking and monitoring targeted drug delivery for efficiently killing drug-resistant cancer cells. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Chemistry Energy Metabolism Lung Lung Diseases Neoplasms Occupational Health Pathology Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Author Keywords: MDR Cancer Cell Biology Cell Cultures Cell Function Cellular Effects Cellular Function Chemical Properties Chemicals Drug Delivery Drugs Graphite Imaging Lung Cancer Lung Cells Metabolism Nanoparticles Pharmacology Q-Graphene Tumor Cell Targeting

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• ISSN:
  1944-8244
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  6
• NIOSHTIC Number:
  nn:20048945
• Citation:
  ACS Appl Mater Interfaces 2016 Feb; 8(6):4048-4055
• Email:
  dan.du@mail.ccnu.edu.cn
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Washington State University
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  ACS Applied Materials and Interfaces
• End Date:
  20180831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:daf6284433a70badca1847fd3c1da89794f3230d0c1d5bce9456e1f43308946740b3ba7d68ff353568fa0f92a037d1f663a97100926efd283fc8bc392909871a
• Download URL:
  https://stacks.cdc.gov/view/cdc/203559/cdc_203559_DS1.pdf
• File Type:
  [PDF - 969.28 KB ]