Oscillometry complements spirometry in evaluation of subjects following toxic inhalation

Details

• Personal Author:
  Berger KI ; Caplan-Shaw C ; Friedman SM ; Goldring RM ; Kazeros A ; Liu M ; Marmor M ; Maslow CB ; Parsia S ; Reibman J ; Shao Y ; Turetz M
• Description:
  The World Trade Center (WTC) destruction released dust and fumes into the environment. Although many community members developed respiratory symptoms, screening spirometry was usually normal. We hypothesised that forced oscillation testing would identify functional abnormalities undetected by spirometry and that symptom severity would relate to magnitude of abnormalities measured by oscillometry. A symptomatic cohort (n=848) from the Bellevue Hospital WTC Environmental Health Center was evaluated and compared to an asymptomatic cohort (n=475) from the New York City Department of Health WTC Health Registry. Spirometry and oscillometry were performed. Oscillometry measurements included resistance (R5) and frequency dependence of resistance (R5-20). Spirometry was normal for the majority of subjects (73.2% symptomatic versus 87.6% asymptomatic, p<0.0001). In subjects with normal spirometry, R5 and R5-20 were higher in symptomatic versus asymptomatic subjects (median (interquartile range) R5 0.436 (0.206) versus 0.314 (0.129) kPa·L-1·s-1, p<0.001; R5-20 0.075 (0.085) versus 0.004 (0.042) kPa·L-1·s-1, p<0.0001). In symptomatic subjects, R5 and R5-20 increased with increasing severity and frequency of wheeze (p<0.05). Measurement of R5-20 correlated with the presence and severity of symptoms even when spirometry was within normal limits. These findings are in accord with small airway abnormalities as a potential explanation of the respiratory symptoms. [Description provided by NIOSH]
• Subjects:
  Dust Hazardous Substances Health Care Facilities Workforce And Services Lung Men Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks Women

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• Keywords:
  Analytical Instruments Clinical Tests Dust Exposure Humans Inhalation Lung Function Medical Equipment Medical Monitoring Medical Screening Oscillography Performance Capability Performance Tests Respiratory Function Respiratory System Disorders Spirometry Toxic Materials World Trade Center WTC

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• ISSN:
  2312-0541
• Document Type:
  Text
• Funding:
  Grant ; Contract ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  1
• Issue:
  2
• NIOSHTIC Number:
  nn:20048848
• Citation:
  ERJ Open Res 2015 Dec; 1(2):00043-2015
• Contact Point Address:
  Joan Reibman, New York University School of Medicine, 550 1st Avenue, Room NB7N24, New York, NY 10016, USA
• Email:
  joan.reibman@nyumc.org
• Federal Fiscal Year:
  2016
• Performing Organization:
  New York City Health and Hospitals Corporation
• Peer Reviewed:
  True
• Start Date:
  20080929
• Source Full Name:
  European Respiratory Journal Open Research
• End Date:
  20110928
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f862db921cf07a49f29ab9c48ceab7891aad59d2c2ae3f0a23b55ec42911d3c656ab3b729251cf0d8b12ee78b5a044841d295293800c6936755eb1a66e09744a
• Download URL:
  https://stacks.cdc.gov/view/cdc/203476/cdc_203476_DS1.pdf
• File Type:
  [PDF - 433.43 KB ]