The effects of JP8 jet fuel on immune cell counts of tank entry workers

Details

• Personal Author:
  Gibson R ; LeMasters GK ; Lockey, James E. ; Rappaport S ; Rhodes AG ; Smith JW ; Yiin JH
• Description:
  Jet fuel is a common occupational exposure among commercial and military maintenance workers. JP8 jet fuel, a military formulation, has been found to have immunotoxic effects in mice but little data exists for humans. The aim of this cross-sectional study was to determine if immune cell counts in the peripheral blood were altered among tank entry workers at three Air Force bases. After adjusting for covariates, tank entry workers (n=45) were found to have higher numbers of white blood cells (p=0.01), neutrophils (p=0.05), and monocytes (p=0.02) when compared to a low exposure group (n=78) and no differences were noted in the numbers of total lymphocytes, T-cells, T-helper cells, T-suppressor cells, Natural Killer cells, and B-cells. Further investigations are under way to evaluate the functional ability of these cells to produce lymphokines and cytokines and modulate the immune system. [Description provided by NIOSH]
• Subjects:
  Animals Benzene Blood Environmental Exposure Laboratories Maintenance Occupational Health Risk Assessment Risk Factors Safety Workplace

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• Keywords:
  Benzenes Blood Cells Cell Function Cellular Function Explosive Gases Exposure Levels Gasoline Immunotoxins Jet Engine Fuels Kerosene Laboratory Animals Maintenance Workers Risk Factors Volatiles Work Environment Workers

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• Publisher:
  Air Force Institute for Operational Health
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  California ; North Carolina ; Ohio ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  100-120
• NIOSHTIC Number:
  nn:20048831
• Citation:
  JP8: Final Risk Assessment. Kendall RK, Smith E, eds. Brooks City-Base, TX: Air Force Institute for Operational Health, 2001 Aug; :100-120
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Editor(s):
  Kendall RK; Smith E
• Federal Fiscal Year:
  2001
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  False
• Start Date:
  19920701
• Source Full Name:
  JP8: Final Risk Assessment
• End Date:
  20070630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3934ce981951a1d1979161cfb7d6c38251432060f6b5d1a43d50e3e1217c0ae807fc9729edd2b557bb34d56ab1685518f097600d16f077f8746005511c4b2c24
• Download URL:
  https://stacks.cdc.gov/view/cdc/203462/cdc_203462_DS1.pdf
• File Type:
  [PDF - 999.52 KB ]