Exposure to polycyclic aromatic hydrocarbons in aluminum pot operators is associated with increased annual decline in FEV1

Details

• Personal Author:
  Bakke B ; Henneberger, Paul K. ; Kongerud JS ; Soyseth V ; Virji, M. Abbas
• Description:
  We conducted a ten-year prospective study in aluminum potroom workers (n=4,546) from seven Norwegian plants. The objective of the study was to investigate the association between exposure to dust, fluorides and polycyclic aromatic hydrocarbons (PAH) and annual decline in lung function (dFEV1). At each annual examination, participants reported their smoking habits and completed spirometry, and the pot operators reported their job according to a predefined classification system. A total of 22,070 spirometric measurements were available for the analyses. Concurrent with the annual examinations, the seven aluminum plants measured exposure to total dust (n=8,109), total fluorides (n=6,734) and PAH (n=3,524). Interval exposure, i.e. the product of current exposure and time elapsed between two consecutive follow-ups, and cumulative exposure, i.e. the sum of interval exposures were used as indices of exposure to total dust, fluorides and PAH. During the follow-up the median current exposure to total dust, fluorides and PAH was 1.77 mg/m3, 0.33 mg/m3 and 19.6 microg/m3, respectively. It turned out that the interval exposure between the second last and the fourth last examination regarding PAH, was the strongest determinant for dFEV1. In this time interval the association between dFEV1 and PAH exposure was 8.3 ml/year/(x10 -2microgxyear/m3) in current smokers and 7.1 ml/year/(x10 -2microgxyear/m3) in never smokers (p<0.0001 for both). In conclusion, exposure to PAH in aluminum pot operators was associated with accelerated dFEV1. [Description provided by NIOSH]
• Subjects:
  Aluminum Compounds Dust Fluorides Health Care Facilities Workforce And Services Hydrocarbons Lung Manufacturing And Industrial Facilities Metal Workers Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety Smokers Tobacco Products

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• Keywords:
  Aluminum Aluminum Compounds Aluminum Industry Cigarette Smoking Dust Exposure Employee Exposure Fluoride Compounds Industrial Environment Industrial Factory Workers Long Term Study Lung Function Medical Examinations Medical Monitoring Polycyclic Aromatic Hydrocarbons Pulmonary Function Pulmonary Function Tests Respiratory Function Respiratory System Disorders Smoking Spirometry

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• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  191
• NIOSHTIC Number:
  nn:20048521
• Citation:
  Am J Respir Crit Care Med 2015 May; 191(Abstract Issue):A2588
• Contact Point Address:
  V. Soyseth, University of Oslo, Lorenskog, Norway
• Email:
  vidar.soyseth@medisin.uio.no
• CAS Registry Number:
  Aluminum (CAS RN 7429-90-5)
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Abstract Issue
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a241408dc2c1827119bfda92e4f215a99ae2a11693b583dcd7715586b99c3e0a4850c3d2d92ffe8239d6f460e77493527b5e0e4a24ba80be60c0efa1b06c1bed
• Download URL:
  https://stacks.cdc.gov/view/cdc/203261/cdc_203261_DS1.pdf
• File Type:
  [PDF - 17.10 KB ]