Development and evaluation of methods

Details

• Personal Author:
  Eller, Peter M. ; Fischbach TJ ; Hull, R. DeLon ; Kennedy, Eugene R. ; Shulmen SA ; Song R
• Description:
  The development and evaluation of analytical methods that are useful, reliable and accurate for industrial hygiene monitoring problems require the application of some general guidelines and evaluation criteria. The guiding objective in this work requires that, over a specified concentration range, the method provide a result that differs no more than +/-25% from the true value 95 times out of 100. The application of consistent evaluation criteria and guidelines is particularly important when methods are developed by different individuals and organizations (e.g., contractors or outside laboratories) and compiled into a single manual. Adherence to guidelines should minimize overlooking potential problems in the methodology during its development, as well as provide cohesiveness and uniformity to the method that is developed. This chapter provides an outline of a generalized set of evaluation criteria prepared by NIOSH researchers for the evaluation of sampling and analytical methodology [NIOSH 1995]. In the development of a sampling and analytical method, there is a logical progression of events that cover a search of the literature to gather pertinent information and the preliminary experimentation for selection of analysis technique and sampling medium. To initiate the development of a method, the identity of the analyte must be as fully defined as possible. Physical and chemical properties of the analyte should be defined so that procedures for proper handling and use of the analyte can be prepared. These also aid in establishment of analyte purity. Potential sources of this information include chemical reference books, health hazard evaluation reports, bulk sample analyses, material safety data sheets, chemical process information, etc. Since innovation is a key element in the sampling and analytical method development process, detailed experiments for the initial development of the sampling approach and optimization of the analytical procedure are better left to the discretion of the researcher. During development, it should be recognized that appropriate, statistically designed experiments will optimize the amount of information obtained. Therefore, consultation with a statistician about appropriately designed experiments will be of value during this phase of the research. [Description provided by NIOSH]
• Subjects:
  Laboratories Occupational Health Safety
• Keywords:
  Analytical Methods Guidelines Industrial Hygiene Monitors Samplers Sampling
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20048066
• Citation:
  NIOSH manual of analytical methods, fifth edition. Ashley K, O'Connor PF, eds. Cincinnati, OH: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, DHHS (NIOSH) Publication No. 2014-151, 2016 Apr; :ME1-ME19
• Editor(s):
  Ashley K; O'Connor PF
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  False
• Source Full Name:
  NIOSH manual of analytical methods, fifth edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6779bdff51eddf4e4dc7995dfaab40c33327ac3ddc5c98ef8ee2633cce07bff15ba49002405b2372a435e2aeefc02f3ae631d6f326d4e7ec78e7a3f97bd7e2a7
• Download URL:
  https://stacks.cdc.gov/view/cdc/202934/cdc_202934_DS1.pdf
• File Type:
  [PDF - 1019.29 KB ]