Inhaled aerosol dosimetry: some current research needs

Details

• Personal Author:
  Darquenne C ; Hoover, Mark D. ; Phalen RF
• Description:
  After the presentation of 60 papers at the conference "Advancing Aerosol Dosimetry Research" (October 24-25, 2014 in Irvine, CA, USA), attendees submitted written descriptions of needed research. About 40 research needs were submitted. The suggestions fell into six broad categories: 1) Access to detailed anatomic data; 2) Access to subject-specific aerosol deposition datasets; 3) Improving current inhaled aerosol deposition models; 4) Some current experimental data needs and hot topics; 5) Linking exposure and deposition modeling to health endpoints; and 6) Developing guidelines for appropriate validation of dosimetry and risk assessment models. Summaries of suggestions are provided here as an update on research needs related to inhaled aerosol dosimetry modeling. Taken together, the recommendations support the overarching need for increased collaborations between dose modelers and those that use the models for risk assessments, aerosol medicine applications, design of toxicology experiments, and extrapolation across species. This paper is only a snapshot in time of perceived research needs from the conference attendees; it does not carry the approval of any agency or other group that plans research priorities or that funds research. [Description provided by NIOSH]
• Subjects:
  Aerosols Lung Occupational Health Particulate Matter Radiation Dosimeters Respiratory System Safety Toxicology
• Keywords:
  Author Keywords: Lung Models Dosimetry Lung Function Models Particle Deposition Particulates Risk Assessment
• ISSN:
  0021-8502
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-5
• Volume:
  99
• NIOSHTIC Number:
  nn:20048007
• Citation:
  J Aerosol Sci 2016 Sep; 99:1-5
• Contact Point Address:
  Chantal Darquenne, Department of Medicine, University of California, San Diego, CA 92093-0623
• Federal Fiscal Year:
  2016
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Aerosol Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2e3244bfbcd8b206fa2f14d103a78b22b9a153934f59236931cb19e0637cfa1b2bcbbc8665cc12c5023ba1d9840334931619ec17de665150c82f9230f4b540ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/202898/cdc_202898_DS1.pdf
• File Type:
  [PDF - 209.76 KB ]