Association between rotating night shift work and risk of coronary heart disease among women

Details

• Personal Author:
  Devore EE ; Kawachi I ; Massa J ; Rosner B ; Schernhammer ES ; Speizer FE ; Stampfer MJ ; Vetter C ; Wegrzyn LR
• Description:
  IMPORTANCE: Prospective studies linking shift work to coronary heart disease (CHD) have been inconsistent and limited by short follow-up. OBJECTIVE: To determine whether rotating night shift work is associated with CHD risk. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of 189,158 initially healthy women followed up over 24 years in the Nurses' Health Studies (NHS [1988-2012]: N=73,623 and NHS2 [1989-2013]: N=115,535). EXPOSURES: Lifetime history of rotating night shift work (≥3 night shifts per month in addition to day and evening shifts) at baseline (updated every 2 to 4 years in the NHS2). MAIN OUTCOMES AND MEASURES: Incident CHD; ie, nonfatal myocardial infarction, CHD death, angiogram-confirmed angina pectoris, coronary artery bypass graft surgery, stents, and angioplasty. RESULTS: During follow-up, 7303 incident CHD cases occurred in the NHS (mean age at baseline, 54.5 years) and 3519 in the NHS2 (mean age, 34.8 years). In multivariable-adjusted Cox proportional hazards models, increasing years of baseline rotating night shift work was associated with significantly higher CHD risk in both cohorts. In the NHS, the association between duration of shift work and CHD was stronger in the first half of follow-up than in the second half (P=.02 for interaction), suggesting waning risk after cessation of shift work. Longer time since quitting shift work was associated with decreased CHD risk among ever shift workers in the NHS2 (P<.001 for trend). CONCLUSIONS AND RELEVANCE: Among women who worked as registered nurses, longer duration of rotating night shift work was associated with a statistically significant but small absolute increase in CHD risk. Further research is needed to explore whether the association is related to specific work hours and individual characteristics. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Cohort Studies Health Personnel Occupational Health Safety Shift Work Schedule Women
• Keywords:
  Cardiac Function Cardiovascular Disease Cohort Studies Heart Disease Long Term Study Nurses Shift Work Work Schedules
• ISSN:
  0098-7484
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  315
• Issue:
  16
• NIOSHTIC Number:
  nn:20047933
• Citation:
  JAMA 2016 Apr; 315(16):1726-1734
• Contact Point Address:
  Céline Vetter, PhD, Channing Division of Network Medicine, 181 Longwood Ave, Boston, MA 02115
• Email:
  celine.vetter@channing.harvard.edu
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Healthcare and Social Assistance
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  Journal of the American Medical Association
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3665404f385a7e53eb8fb1537ef905f17a1bd86b941c3d6b55c886ad2d1caa2efbfb707219c4a72bd132befd18795b0633aec4060a738ca3ffbf6ea329740f77
• Download URL:
  https://stacks.cdc.gov/view/cdc/202866/cdc_202866_DS1.pdf
• File Type:
  [PDF - 212.29 KB ]