Enhanced viral interferon induction by the mineral wollastonite

Details

• Personal Author:
  Boehlecke, Brian A. ; Booth JA ; Hahon N ; Merchant, James A.
• Description:
  The in vitro activity of the fibrous mineral wollastonite (CaSiO3) on the interferon system was investigated. Wollastonite enhanced the induction of interferon by influenza virus in mammalian (LLC-MK2) cell monolayers but the mineral per se did not induce interferon. The magnitude of enhanced interferon induction was dependent on mineral concentration, particle size, and its time and sequence of addition onto cell monolayers. A "synergistic effect" on viral induction of interferon was noted when cell cultures were interferon-primed and then treated with wollastonite. Interferon yields were significantly higher than those obtained by the use of either the primer or wollastonite alone. That influenza virus multiplied in wollastonite-treated cells to a level that was sevenfold less than that in normal cells was associated with increased interferon production. The ability of interferon to confer antiviral cellular resistance was not impaired by wollastonite. The findings of this study suggest that the incorporation of wollastonite in appropriate interferon inducer-host cell systems may be useful for augmenting interferon production. [Description provided by NIOSH]
• Subjects:
  Communicable Diseases Influenza, Human Minerals Occupational Health Particulate Matter Safety Viral Diseases
• Keywords:
  Fibers Influenza Viral Diseases Viral Infections
• ISSN:
  2332-4007
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  ALOSH - Appalachian Laboratory for Occupational Safety and Health
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  49-60
• Volume:
  1
• Issue:
  1
• NIOSHTIC Number:
  nn:20047874
• Citation:
  J Interferon Res 1980 Fall; 1(1):49-60
• Contact Point Address:
  Nicholas Hahon, USPHS, ALOSH, 944 Chestnut Ridge Road, Morgantown, WV 26505
• CAS Registry Number:
  Wollastonite (Ca(SiO3)) (CAS RN 13983-17-0)
• Federal Fiscal Year:
  1980
• Peer Reviewed:
  False
• Source Full Name:
  Journal of Interferon Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9d6bb18a289f6cf8ab0d26429e6b0248b35db5d182427f1b0f5a89138cbc3022b1f7bc9649f9198cb2b12b457abe8455c4b560ebca55e8fd26de3d44c96cde54
• Download URL:
  https://stacks.cdc.gov/view/cdc/202826/cdc_202826_DS1.pdf
• File Type:
  [PDF - 2.77 MB ]