Correlation of lung crackles with surface deformation using holographic interferometry

Details

• Personal Author:
  Afshari AA ; Frazer DG ; Stanley CF
• Description:
  The primary function of the lung, i.e. gas exchange, occurs in peripheral units termed alveoli. Diagnosis of lung dysfunction is therefore dependent on techniques to evaluate the status of the peripheral airways. Since these airways and alveoli are very small, it is difficult to determine directly how there function or how the function is changing due to disease. Yet this understanding is critical to the design of instrumentation to detect early changes in lung function due to disease. An interesting hypothesis describing one aspect of small airway function has been proposed by Frazer as gas trapping due to the formation of menisci in the airways. An additional study proposes that the breaking and possibly the formation of these menisci could generate lung sounds, i.e. crackles. These lung sounds were recorded by placing a microphone at the trachea of an excised rat lung. The lung was degassed and then inflated and deflated. At points along the path of inflation, lung sounds were recorded. However, determination of the origin of the sounds was not attempted due to the difficulties induced by contracting the lung surface with a microphone. The purpose of this paper is to describe a non-contracting, whole field technique to monitor and describe the movement of the lung surface during inflation - deflation cycles. [Description provided by NIOSH]
• Subjects:
  Diagnosis Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Analytical Processes Diagnostic Techniques Diagnostic Tests Lung Disease Lung Disorders Lung Function Medical Screening Respiratory Diseases Respiratory Function Respiratory Function Tests Respiratory System Disorders

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• ISBN:
  9789992281604
• Publisher:
  The American Society of Mechanical Engineers
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  13
• Volume:
  15
• NIOSHTIC Number:
  nn:20047854
• Citation:
  1989 Advances in Bioengineering: Winter Annual Meeting of the American Society of Mechanical Engineers, December 10-15, 1989, San Francisco, California. Rubinsky B, ed. New York: The American Society of Mechanical Engineers, 1989 Jun; 15:13
• Contact Point Address:
  D. G. Frazer, National Institute for Occupational Safety and Health, Morgantown, WV 26505
• Editor(s):
  Rubinsky B
• Federal Fiscal Year:
  1989
• Peer Reviewed:
  False
• Source Full Name:
  1989 Advances in Bioengineering: Winter Annual Meeting of the American Society of Mechanical Engineers, San Francisco, California, December 10-15, 1989
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:44844077393b22c704da8197a4e88bf3a9a868ae79842f3ff1d812b761b7d2dac36a7ed6c35d776eafac9e07a449c6f3b23d909a8c1c72606e0b6e57520a11f0
• Download URL:
  https://stacks.cdc.gov/view/cdc/202813/cdc_202813_DS1.pdf
• File Type:
  [PDF - 661.63 KB ]