Carbon nanotube and asbestos exposures induce overlapping but distinct profiles of lung pathology in non-Swiss albino CF-1 mice

Details

• Personal Author:
  Birch, M. Eileen ; Carreira VS ; Frank EA ; Yadav JS
• Description:
  Carbon nanotubes (CNTs) are emerging as important occupational and environmental toxicants owing to their increasing prevalence and potential to be inhaled as airborne particles. CNTs are a concern because of their similarities to asbestos, which include fibrous morphology, high aspect ratio, and biopersistence. Limitations in research models have made it difficult to experimentally ascertain the risk of CNT exposures to humans and whether these may lead to lung diseases classically associated with asbestos, such as mesothelioma and fibrosis. In this study, we sought to comprehensively compare profiles of lung pathology in mice following repeated exposures to multiwall CNTs or crocidolite asbestos (CA). We show that both exposures resulted in granulomatous inflammation and increased interstitial collagen; CA exposures caused predominantly bronchoalveolar hyperplasia, whereas CNT exposures caused alveolar hyperplasia of type II pneumocytes (T2Ps). T2Ps isolated from CNT-exposed lungs were found to have upregulated proinflammatory genes, including interleukin 1β (IL-1β), in contrast to those from CA exposed. Immunostaining in tissue showed that while both toxicants increased IL-1β protein expression in lung cells, T2P-specific IL-1β increases were greater following CNT exposure. These results suggest related but distinct mechanisms of action by CNTs versus asbestos which may lead to different outcomes in the 2 exposure types. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Asbestos Fibrosis Genetics Hazardous Substances Inorganic Chemicals Laboratories Lung Diseases Neoplasms Occupational Health Particulate Matter Pathology Respiratory Tract Diseases Safety

  More +
• Keywords:
  Airborne Particles Author Keywords: Carbon Nanotubes Carbon Nanotubes Comparative Pathology Crocidolite Asbestos Fiber Toxicology Fibrous Bodies Genes Laboratory Animals Lung Lung Disease Mesothelioma Models Mouse Particulates Toxins

  More +
• ISSN:
  0192-6233
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  211-225
• Volume:
  44
• Issue:
  2
• NIOSHTIC Number:
  nn:20047759
• Citation:
  Toxicol Pathol 2016 Feb; 44(2):211-225
• Contact Point Address:
  Jagjit S. Yadav, University of Cincinnati College of Medicine, Kettering Laboratory Complex, 160 Panzeca Way, Cincinnati, OH 45267
• Email:
  jagjit.yadav@uc.edu
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Toxicologic Pathology
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:914540603f30bfaa9caf39c62dcb68e82599e1a39056ae515a8109577373f5c095cd908e6e52eb5526afafc13c3e40f4fc9f1ff3da4e724c4926aa461f9275fe
• Download URL:
  https://stacks.cdc.gov/view/cdc/202747/cdc_202747_DS1.pdf
• File Type:
  [PDF - 3.07 MB ]