CD30 is a potential therapeutic target in malignant mesothelioma

Details

• Personal Author:
  Dabir S ; Dowlati A ; Fu P ; Kresak A ; Wildey G ; Yang M
• Description:
  CD30 is a cytokine receptor belonging to the TNF superfamily (TNFRSF8) that acts as a regulator of apoptosis. The presence of CD30 antigen is important in the diagnosis of Hodgkin disease and anaplastic large cell lymphoma. There have been sporadic reports of CD30 expression in nonlymphoid tumors, including malignant mesothelioma. Given the remarkable success of brentuximab vedotin, an antibody-drug conjugate directed against CD30 antigen, in lymphoid malignancies, we undertook a study to examine the incidence of CD30 in mesothelioma and to investigate the ability to target CD30 antigen in mesothelioma. Mesothelioma tumor specimens (N = 83) were examined for CD30 expression by IHC. Positive CD30 expression was noted in 13 mesothelioma specimens, primarily those of epithelial histology. There was no significant correlation of CD30 positivity with tumor grade, stage, or survival. Examination of four mesothelioma cell lines (H28, H2052, H2452, and 211H) for CD30 expression by both FACS analysis and confocal microscopy showed that CD30 antigen localized to the cell membrane. Brentuximab vedotin treatment of cultured mesothelioma cells produced a dose-dependent decrease in cell growth and viability at clinically relevant concentrations. Our studies validate the presence of CD30 antigen in a subgroup of epithelial-type mesothelioma tumors and indicate that selected mesothelioma patients may derive benefit from brentuximab vedotin treatment. [Description provided by NIOSH]
• Subjects:
  Antigens Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: Mesothelioma Brentuximab Vedotin CD30 Cell Function Cellular Function Cytokines Immunohistochemistry Malignancy Mesothelioma Predictive Biomarkers Tumors

  More +
• ISSN:
  1535-7163
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• Issue:
  3
• NIOSHTIC Number:
  nn:20047619
• Citation:
  Mol Cancer Ther 2015 Mar; 14(3):740-746
• Contact Point Address:
  Afshin Dowlati, MD, Department of Medicine, Division of Hematology and Oncology, Case Comprehensive Cancer Center and University Hospitals Case Medical Center, 11100 Euclid Avenue, Mail Stop LKS 5079, Cleveland, Ohio, 44016
• Email:
  afshin.dowlati@case.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Construction ; Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Molecular Cancer Therapeutics
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:71623bff4d8dd507413af726741012c183f150dd63b7ba7cc515bfe1a2c254fdd99304756b6b380b3b36848b120b197db11b7c4a21b78dabc5e0cf618701c981
• Download URL:
  https://stacks.cdc.gov/view/cdc/202634/cdc_202634_DS1.pdf
• File Type:
  [PDF - 869.85 KB ]