The World Trade Center disaster and intrauterine growth restriction

Details

• Personal Author:
  Berkowitz GS ; Holzman IR ; Janevic TM ; Landrigan, Philip J. ; Wolff MS ; Yehuda R
• Description:
  The fire and collapse of the World Trade Center (WTC) was the largest acute environmental disaster that ever has befallen New York City. The resulting toxicants included benzene, polycyclic aromatic hydrocarbons (PAHs), and heavy metals. To evaluate whether the toxic exposures and associated stress were associated with impaired fetal growth or other adverse pregnancy outcomes, we established a cohort of 187 pregnant women who were inside or near the WTC on 9/11. As a comparison group, we utilized all private patients who delivered at Mount Sinai Medical Center on the Upper East side of Manhattan during the same time period (n=2367). No significant differences were found for mean gestational age, mean birthweight, the frequency of preterm births, or incidence of low birth weight. However, the WTC cohort had an almost twofold (aOR=1.90, 95% CI=1.04 - 3.46) increased risk of intrauterine growth restriction (IUGR). No association was evident between post-traumatic stress symptomatology and pregnancy outcome. Previous studies have found associations between particulate air pollution and IUGR as well as preterm births. High levels of PAH-DNA adducts have also been associated with reduced birth size. Thus, it is possible that both the particulate as well as the PAH exposure affect intrauterine growth. Our observation of an apparent association between maternal exposure to the WTC disaster and IUGR suggests that this event had a detrimental impact on exposed pregnancies. [Description provided by NIOSH]
• Subjects:
  Aging Air Pollutants, Occupational Air Pollution, Indoor Alkalies Benzene Demography Dust Hydrocarbons Metals Metals, Heavy Occupational Health Particulate Matter Polycyclic Aromatic Hydrocarbons Risk Assessment Risk Factors Safety Women

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• Keywords:
  Age-groups Air-contamination Alkali-metals Benzenes Cements Demographic-characteristics Exposure-levels Heavy-metals Humans Leukocytes Metal-dusts Metallic-compounds Metallic-dusts Particulate-dust Particulates Pollution Polycyclic-aromatic-hydrocarbons Prenatal-exposure Risk-factors Statistical-analysis

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  157
• Issue:
  11
• NIOSHTIC Number:
  nn:20047468
• Citation:
  Am J Epidemiol 2003 Jun; 157(11):S67
• CAS Registry Number:
  Benzene (CAS RN 71-43-2)
• Federal Fiscal Year:
  2003
• Performing Organization:
  Mount Sinai School of Medicine of New York
• Peer Reviewed:
  False
• Start Date:
  20040601
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20100531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d24db8d17f97bb4433334edda026c30cd377e169233aea18d7b076febe9a2afbef807eb33baedebd70b5ca457729de54d4d3f349bb7eec9a765b92ed46c686d
• Download URL:
  https://stacks.cdc.gov/view/cdc/202524/cdc_202524_DS1.pdf
• File Type:
  [PDF - 1.03 MB ]