Exposure to bisphenol-A and reproductive hormones among male adults

Details

• Personal Author:
  Chen J ; Gao E ; Li D-K ; Liu X ; Miao M ; Sun F ; Wang J ; Yuan W ; Zhou Z
• Description:
  BACKGROUND: Bisphenol A (BPA) is a suspected human endocrine disruptor which is widely used. METHODS: In order to determine whether urine BPA level is associated with serum reproductive hormone levels among male adults, we carried out a cross-sectional study in China. We recruited 592 male workers and collected their urine samples for BPA measurement. We also collected blood samples and examined serum reproductive hormones. We used multiple linear regression and log-binomial model to examine associations between urine BPA level and hormone levels after controlling for age and smoking status. RESULTS: An increased urine BPA level was associated with increased prolactin (p<0.001), estradiol (p<0.001), sex hormone-binding globulin level (p=0.001), and a reduced androstenedione (p<0.001) and free androgen index level (p=0.021). Males, whose urine BPA level was in the 2nd, 3rd and highest quartiles, had respectively 1.58, 1.33 and 3.09-fold increased prevalence of having a high prolactin level (>P75 level). The highest quartile of BPA level was associated with 1.63 and 1.50-fold increased prevalence of having a high estradiol and elevated sex hormone-binding globulin level. Males with higher quartile of BPA level had a lower inhibin B level. CONCLUSION: High BPA exposure is associated with increased prolactin, estradiol and sex hormone-binding globulin level in males, and may contribute to male infertility. [Description provided by NIOSH]
• Subjects:
  Endocrine System Endocrine System Diseases Men Occupational Health Public Health Risk Assessment Risk Factors Safety Urine Urogenital Diseases Urogenital System

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• Keywords:
  Author Keywords: Bisphenol A Endocrine-function Endocrine-system Endocrine-system-disorders Endocrine Disruptor Exposure-levels Hazards Hormones Humans LINE-1 Methylation Models Public-health Reproduction Reproductive-effects Reproductive-hazards Risk-factors Spermatozoa Urinalysis

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• ISSN:
  1382-6689
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  39
• Issue:
  2
• NIOSHTIC Number:
  nn:20047379
• Citation:
  Environ Toxicol Pharmacol 2015 Mar; 39(2):934-941
• Contact Point Address:
  De-Kun Li, Institute of Planned Parenthood Research, Shanghai 200032, China
• Federal Fiscal Year:
  2015
• Performing Organization:
  Kaiser Foundation Research Institute
• Peer Reviewed:
  True
• Start Date:
  20030930
• Source Full Name:
  Environmental Toxicology and Pharmacology
• End Date:
  20110929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bd29f249cf508d20c157fb16670fa839afaf091cdf8fa98315cdcc405b822081c351788493104b10a3105b30e07e17441ed9bfbcf1cf158580cee71bb4d2dd60
• Download URL:
  https://stacks.cdc.gov/view/cdc/202463/cdc_202463_DS1.pdf
• File Type:
  [PDF - 675.78 KB ]