Cancer in World Trade Center responders: findings from multiple cohorts and options for future study

Details

• Personal Author:
  Boffetta P ; Brackbill R ; Cone, James E. ; Farfel M ; Holden W ; Li J ; Lucchini R ; Prezant D ; Stellman SD ; Wallenstein S ; Webber MP ; Zeig-Owen R
• Description:
  Background: Three longitudinal studies of cancer incidence in varied populations of World Trade Center responders have been conducted. Methods: We compared the design and results of the three studies. Results: Separate analyses of these cohorts revealed excess cancer incidence in responders for all cancers combined and for cancers of the thyroid and prostate. Methodological dissimilarities included recruitment strategies, source of cohort members, demographic characteristics, overlap between cohorts, assessment of WTC and other occupational exposures and confounders, methods and duration of follow-up, approaches for statistical analysis, and latency analyses. Conclusions: The presence of three cohorts strengthens the effort of identifying and quantifying the cancer risk; the heterogeneity in design might increase sensitivity to the identification of cancers potentially associated with exposure. The presence and magnitude of an increased cancer risk remains to be fully elucidated. Continued long-term follow up with minimal longitudinal dropout is crucial to achieve this goal. [Description provided by NIOSH]
• Subjects:
  Carcinogens Emergency Responders Epidemiology Firefighters Law Enforcement Men Neoplasms Occupational Health Risk Assessment Risk Factors Safety September 11 Terrorist Attacks Women Workplace

  More +
• Keywords:
  Author Keywords: World Trade Center Cancer Cohort Study Emergency-responders Exposure-levels Fire-fighters Humans Police-officers Rescue-workers Risk-factors Surveillance Work-environment Worker-health Workers

  More +
• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Cooperative Agreement ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  96-105
• Volume:
  59
• Issue:
  2
• NIOSHTIC Number:
  nn:20047225
• Citation:
  Am J Ind Med 2016 Feb; 59(2):96-105
• Contact Point Address:
  Paolo Boffetta, MD, MPH, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1130, New York, NY 10029
• Email:
  paolo.boffetta@mssm.edu
• Federal Fiscal Year:
  2016
• Performing Organization:
  New York City Health/Mental Hygiene
• Peer Reviewed:
  True
• Start Date:
  20090430
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c9a39d4b78ef0804389d50843198f57ee0992487461ea61929809ff69f1b51625b9ba7c005f4c95fb6ce7babd7ca676d1214bdfd42bfdaa7c188713f2346273f
• Download URL:
  https://stacks.cdc.gov/view/cdc/202379/cdc_202379_DS1.pdf
• File Type:
  [PDF - 123.01 KB ]