Plastics and carcinogenesis: the example of vinyl chloride

Details

• Personal Author:
  Brandt-Rauf PW ; Kovvali G ; Li Y ; Long C ; Marion M-J ; Monaco R
• Description:
  The manufacture, use and disposal of various plastics can pose numerous health risks, including the risk of cancer. A model example of carcinogenic risk from plastics is provided by polyvinyl chloride, since it is composed of the known human carcinogen vinyl chloride (VC). In recent years, much has been learned about the molecular biological pathways of VC carcinogenesis. This has led to molecular epidemiologic studies of VC carcinogenesis in exposed human populations which have identified useful biomarkers of exposure, effect and susceptibility for VC. These studies have in turn provided the basis for new molecular approaches for the prevention and treatment of VC cancers. This model could have much wider applicability for many other carcinogenic exposures and many other human cancers. [Description provided by NIOSH]
• Subjects:
  Biomarkers Carcinogens Chlorine Chlorine Compounds DNA Energy Metabolism Epidemiology Genetics Neoplasms Occupational Health Plastics Risk Assessment Risk Factors Safety Vinyl Chloride Waste Management

  More +
• Keywords:
  Author Keywords: Carcinogenesis Cancer Carcinogenesis Cell-metabolism Cellular-function Chemoprevention Chemotherapy Chlorides Chlorinated-vinyls Disease-prevention DNA-damage Gene-mutation Genes Humans Metabolism Models Molecular-biology Molecular-structure Molecular Biology Molecular Epidemiology Mutation Plastic-products Plastics-industry Prophylaxis Proteins Risk-analysis Risk-factors Vinyl-plastics Vinyl Chloride Waste-disposal

  More +
• ISSN:
  0974-6773
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; New Jersey ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  5
• Volume:
  11
• Issue:
  1
• NIOSHTIC Number:
  nn:20047191
• Citation:
  J Carcinog 2012 Mar; 11(1):5
• Contact Point Address:
  Paul Wesley Brandt-Rauf, Division of Environmental and Occupational Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, IL USA
• Email:
  pwb1@uic.edu
• CAS Registry Number:
  Poly(vinyl chloride) (CAS RN 9002-86-2) ; Vinyl chloride (CAS RN 75-01-4)
• Federal Fiscal Year:
  2012
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Journal of Carcinogenesis
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:19edc210a15f35be02573efceb3d684f05f65e43d26a604f78568cedded2a6f434058da2e123caac913030309d52c5d139984259ce46fc5f3cccb90f1f1de00d
• Download URL:
  https://stacks.cdc.gov/view/cdc/202353/cdc_202353_DS1.pdf
• File Type:
  [PDF - 317.43 KB ]