Influence of respiratory air space dimensions on aerosol deposition

Details

• Personal Author:
  Lippmann, Morton ; Palmes ED
• Description:
  Models used to estimate both total and regional deposition of aerosols in the human respiratory tract have been proposed by a number of individuals and groups. Although the values chosen by different investigators for dimensions of airways or other air spaces may differ significantly from each other, there is the common assumption that the normal human respiratory tract is structurally uniform and that dimensions and branching patterns may be considered as constants in the deposition equations. There has been, therefore, considerable emphasis on estimating the effects of particle size, size dispersion, tidal volume and respiratory frequency. Much less attention has been paid to the normal intersubject variability of the size of air spaces in spite of the obvious influence this would have on aerosol deposition. Work on deposition from our own laboratories, as well as published results of others on pulmonary anatomy, has lead to the conclusion that there is considerable anatomic variability among normal subjects. Aerosol deposition in individuals examined under nearly identical conditions has also shown considerable variability. This paper will discuss the similarity in range of anatomical differences and differences in deposition and the probable relationship between the two. [Description provided by NIOSH]
• Subjects:
  Aerosols Dust Lung Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Aerosol-particles Models Particle-aerodynamics Particulate-dust Physiological-factors Physiological-testing Physiology Pulmonary-system Respirable-dust
• ISBN:
  9780080205601
• Publisher:
  Pergamon Press
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Proceedings
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  127-136
• NIOSHTIC Number:
  nn:20047136
• Citation:
  Inhaled particles IV: proceedings of an international symposium 22-26 September 1975, organized by the British Occupational Hygiene Society, Edinburgh, Scotland, United Kingdom. Walton WH, ed. Oxford: Pergamon Press, 1977 Jan; 4(Pt 1):127-136
• Editor(s):
  Walton WH
• Federal Fiscal Year:
  1977
• Performing Organization:
  New York University, New York, New York
• Peer Reviewed:
  True
• Part Number:
  1
• Start Date:
  19720801
• Source Full Name:
  Inhaled particles IV: proceedings of an international symposium 22-26 September 1975, organized by the British Occupational Hygiene Society, Edinburgh, Scotland, United Kingdom
• End Date:
  19770131
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0bea678d3f22ecb7c238033ad14354f2f1c9c2df8b70138aa425cd6b34169fa1d4fcc2db524dda1e4ec274f08aabed99a2735b1f1bb84734018ebabf8d7bbb1a
• Download URL:
  https://stacks.cdc.gov/view/cdc/202318/cdc_202318_DS1.pdf
• File Type:
  [PDF - 4.13 MB ]