The association of body size in early to mid-life with adult urinary 6-sulfatoxymelatonin levels among night shift health care workers

Details

• Personal Author:
  Brown SB ; Devore EE ; Hankinson SE ; Massa J ; Pierre-Paul J ; Ramin CA ; Schernhammer ES ; Wegrzyn LR
• Description:
  Background: Adult body mass index (BMI) has been associated with urinary melatonin levels in humans; however, whether earlier-life body size is associated with melatonin, particularly among night shift workers, remains unknown. Methods: We evaluated associations of birth weight, body shape (or somatotype) at ages 5 and 10, BMI at age 18 and adulthood, weight change since age 18, waist circumference, waist to hip ratio, and height with creatinine-adjusted morning urinary melatonin (6-sulfatoxymelatonin, aMT6s) levels among 1,343 healthy women (aged 32-53 at urine collection, 1996-1999) in the Nurses' Health Study (NHS) II cohort. Using multivariable linear regression, we computed least-square mean aMT6s levels across categories of body size, and evaluated whether these associations were modified by night shift work. Results: Adult BMI was inversely associated with aMT6s levels (mean aMT6s levels = 34 vs. 50 ng/mg creatinine, comparing adult BMI >/= 30 vs. <20 kg/m2; Ptrend <0.0001); however, other measures of body size were not related to aMT6s levels after accounting for adult BMI. Night shifts worked prior to urine collection, whether recent or cumulatively over time, did not modify the association between adult BMI and aMT6s levels (e.g., P interaction = 0.72 for night shifts worked within two weeks of urine collection). Conclusions: Our results suggest that adult BMI, but not earlier measures of body size, is associated with urinary aMT6s levels in adulthood. These observations did not vary by night shift work status, and suggest that adult BMI may be an important mechanism by which melatonin levels are altered and subsequently influence chronic disease risk. [Description provided by NIOSH]
• Subjects:
  Aging Body Weight Circadian Rhythm Health Personnel Occupational Health Risk Assessment Risk Factors Safety Shift Work Schedule Urine Women

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• Keywords:
  Age-groups AMT6s Author Keywords: Body Mass Index Birth Weight Body-weight Circadian-rhythms Diseases Health-care-personnel Height Height-factors Humans Mathematical-models Melatonin Nurses Nursing Physiological-measurements Risk-factors Shift-work Shift-workers Somatotype Statistical-analysis Urinalysis Weight-factors Weight-measurement Work-intervals

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• ISSN:
  1471-2458
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• NIOSHTIC Number:
  nn:20047038
• Citation:
  BMC Public Health 2015 May; 15:467
• Contact Point Address:
  Cody A Ramin, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
• Email:
  cor080@mail.harvard.edu
• CAS Registry Number:
  Melatonin (CAS RN 73-31-4)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Healthcare and Social Assistance
• Performing Organization:
  Brigham and Women's Hospital, Inc., Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20100801
• Source Full Name:
  BMC Public Health
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f858e871cc065c5cb008ccd5059a95acac4f795b510111b65c7e1e687f11c991c79091bdbc2497101ebcdedf17547131558ede7368f470903b28fc706019cd2d
• Download URL:
  https://stacks.cdc.gov/view/cdc/202269/cdc_202269_DS1.pdf
• File Type:
  [PDF - 329.27 KB ]