Seroepidemiologic study of human infections with spotted fever group Rickettsiae in North Carolina

Details

• Personal Author:
  Bouyer DH ; Daves G ; Delisle J ; Johnson J ; Mendell NL ; Meshnick SR ; Moncayo AC ; Nicholson WL ; Reber J ; Vaughn MF ; Williams C
• Description:
  Increasing entomologic and epidemiologic evidence suggests that spotted fever group rickettsiae (SFGR) other than Rickettsia rickettsii are responsible for spotted fever rickettsioses in the United States. A retrospective seroepidemiologic study was conducted on stored acute- and convalescent-phase sera that had been submitted for Rocky Mountain spotted fever testing to the North Carolina State Laboratory of Public Health. We evaluated the serologic reactivity of the paired sera to R. rickettsii, Rickettsia parkeri, and Rickettsia amblyommii antigens. Of the 106 eligible pairs tested, 21 patients seroconverted to one or more antigens. Cross-reactivity to multiple antigens was observed in 10 patients, and seroconversions to single antigens occurred in 11 patients, including 1 against R. rickettsii, 4 against R. parkeri, and 6 against R. amblyommii. Cross-absorption of cross-reactive sera and/or Western blots identified two presumptive cases of infection with R. parkeri, two presumptive cases of infection with R. rickettsii, and one presumptive case of infection with R. amblyommii. These findings suggest that species of SFGR other than R. rickettsii are associated with illness among North Carolina residents and that serologic testing using R. rickettsii antigen may miss cases of spotted fever rickettsioses caused by other species of SFGR. [Description provided by NIOSH]
• Subjects:
  Antibodies Antigens Bacterial Infections Blood Disease Vectors Epidemiology Hematologic Tests Immune System Laboratories Microbiology Occupational Health Safety

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• Keywords:
  Antibody-response Bacteria Bacterial-disease Bacterial-infections Blood-samples Blood-serum Blood-tests Disease-incidence Disease-vectors Humans Immunological-tests Immunology Laboratory-testing Microorganisms Serological-techniques Serology

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• ISSN:
  0095-1137
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; North Carolina ; OSHA Region 4 ; OSHA Region 6 ; Tennessee ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  52
• Issue:
  11
• NIOSHTIC Number:
  nn:20046872
• Citation:
  J Clin Microbiol 2014 Nov; 52(11):3960-3966
• Contact Point Address:
  Meagan Vaughn, Rho, Inc., Chapel Hill, North Carolina, USA
• Email:
  meagan_vaughn@rhoworld.com
• Federal Fiscal Year:
  2015
• Performing Organization:
  University of North Carolina, Chapel Hill
• Peer Reviewed:
  True
• Start Date:
  20100901
• Source Full Name:
  Journal of Clinical Microbiology
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b73f943bbc7a0ddfdcbb84c7d7430b72ec79172264ad4704ae90975551cfe0790e614aa8449ee7ec36d8eed46faa5eb3565f7f3178b8934d2b721d04fdaa05e6
• Download URL:
  https://stacks.cdc.gov/view/cdc/202151/cdc_202151_DS1.pdf
• File Type:
  [PDF - 465.13 KB ]