Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure

Details

• Personal Author:
  Liu J ; Redlich CA ; Wisnewski AV
• Description:
  Work-related asthma may be triggered by large molecules (such as proteins from fish or from natural rubber latex) as well as by small, highly reactive molecules, such as diisoccyanates (including TDI and MDI). MDI is commonly used to harden spray polyurethane foam (SPF) and is a major cause of work-related asthma, lung disease and dermatitis among SPF applicators. While prior information suggests that small molecules cause allergic responses by binding to large proteins in the body, the exact mechanism is not known. Researchers explored one potential mechanism for transporting MDI by testing chemical reactions in laboratory conditions simulating conditions in the human body. Chemical products were then reacted with antibodies obtained from blood samples from construction workers who had worked with MDI as well as from unexposed control subjects. The results suggest a chemical reaction that may help shuttle MDI into the bloodstream and distribute it throughout the body. Better understanding of this mechanism may help prevent or treat asthma. [Description provided by NIOSH]
• Subjects:
  Antibodies Asthma Asthma, Occupational Blood Chemistry Construction Industry Hematologic Tests Hypersensitivity Immune System Isocyanates Laboratories Methane Occupational Health Polyurethanes Safety Workplace

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• Keywords:
  Allergens Allergies Antibody-response Blood-samples Bronchial-asthma Chemical-reactions Construction Construction-industry Construction-workers Humans Immune-reaction Laboratory-testing Methanes Methyl-compounds Molecular-structure Polyurethane-foams Proteins Thiones Work-environment Worker-health

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• Publisher:
  CPWR-The Center for Construction Research and Training
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Report
• Place as Subject:
  Connecticut ; Maryland ; OSHA Region 1 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1
• NIOSHTIC Number:
  nn:20046756
• Citation:
  Silver Spring, MD: CPWR-The Center for Construction Research and Training, 2014 Mar; :1
• Email:
  adam.wisnewski@yale.edu
• CAS Registry Number:
  Diphenylmethane diisocyanate (CAS RN 101-68-8)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Construction
• Performing Organization:
  CPWR - The Center for Construction Research and Training, Silver Spring, Maryland
• Peer Reviewed:
  False
• Start Date:
  20090901
• Source Full Name:
  Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:248bbd147a4f697ea401b31cedaa138831a9de9cd9282c934c0ac92da3a561be4511dff6f91cd7b82cbd94b8e1b4aa986fa86ccbfd200d1c5f0b3300210a7603
• Download URL:
  https://stacks.cdc.gov/view/cdc/202086/cdc_202086_DS1.pdf
• File Type:
  [PDF - 42.78 KB ]