Carbon nanotubes size classification, characterization and nasal airway deposition

Details

• Personal Author:
  Cheng YS ; Su W-C
• Description:
  Workers and researchers in the carbon nanotubes (CNT)-related industries and laboratories might be exposed to CNT aerosols while generating and handling CNT materials. From the viewpoint of occupational health, it is essential to study the deposition of CNT aerosol in the human respiratory tract to investigate the potential adverse health effects. In this study, a human nasal airway replica and two types of CNT materials were employed to conduct CNT nasal airway deposition studies. The two CNT materials were aerosolized by a nebulizer-based wet generation method, with size classified by three designated classification diameters (51, 101 and 215 nm), and then characterized individually in terms of their morphology and aerodynamic diameter. The nasal deposition experiments were carried out by delivering the size classified CNTs into the nasal airway replica in three different inspiratory flow rates. From the characterization study, it showed that the morphology of the size classified CNTs could be in a variety of complex shapes with their physical dimension much larger than their classification diameter. In addition, it was found that the aerodynamic diameters of the classified CNTs were slightly smaller than their classification diameter. The nasal deposition data acquired in this study showed that the deposition efficiency of CNTs in the nasal airway were generally less than 0.1, which implies that the majority of the CNTs inhaled into the nose could easily penetrate through the entire nasal airway and transit further down to the lower airways, possibly causing adverse health effects. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Inhalation Exposure Laboratories Manufacturing And Industrial Facilities Nose Occupational Exposure Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Sense Organs

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• Keywords:
  Aerosol-generators Airborne-particles Airway-resistance Author Keywords: Aerosol Biological-effects Carbon-compounds Carbon Nanotubes Employee-exposure Humans Industrial-engineering Industrial-processes Inhalants Laboratory-testing Morphology Nanotechnology Nasal-cavity Nasal Airway Particle-aerodynamics Physical-properties Respiratory-system-disorders

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• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  26
• Issue:
  14
• NIOSHTIC Number:
  nn:20046666
• Citation:
  Inhal Toxicol 2014 Dec; 26(14):843-852
• Contact Point Address:
  Wei-Chung Su, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA
• Email:
  wsu@LRRI.org
• CAS Registry Number:
  Carbon (CAS RN 7440-44-0)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Lovelace Biomedical & Environmental Research
• Peer Reviewed:
  True
• Start Date:
  20120901
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20160831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5ec1d7a0273aee3255e4fe6a7591355fc5a1cb958574b81f3992831418d68c7019f2277508295ed49ce4e54fbd92dd6798b54cb3acf240d8fabe1d91163ab6b9
• Download URL:
  https://stacks.cdc.gov/view/cdc/202024/cdc_202024_DS1.pdf
• File Type:
  [PDF - 15.13 MB ]