Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust

Details

• Personal Author:
  Bauer CD ; Heires AJ ; Nordgren TM ; Poole JA ; Romberger DJ ; West WW ; Wyatt TA
• Description:
  Agriculture industry workers are at a higher risk for chronic bronchitis and obstructive pulmonary diseases, and current therapeutics are not entirely effective. We previously found that the specialized proresolving lipid mediator maresin-1 (MaR1) reduced proinflammatory cytokine release and intracellular adhesion molecule-1 (ICAM-1) expression in bronchial epithelial cells exposed to extracts of organic dust (DE) derived from swine confinement facilities in vitro. The objective of this study was to determine whether MaR1 is effective at limiting lung inflammation associated with acute and repetitive exposures to DE in an established murine model of inhalant dust exposures. C57Bl/6 mice were treated with MaR1 or vehicle control and intranasally instilled with DE once or daily for 3 weeks. Bronchioalveolar lavage fluid was analyzed for total and differential cell counts and proinflammatory cytokine levels, and lung tissues were assessed for histopathology and ICAM-1 expression. In both single and repetitive DE exposure studies, MaR1 significantly decreased bronchoalveolar lavage neutrophil infiltration, interleukin 6, tumor necrosis factor a, and chemokine C-X-C motif ligand 1 levels without altering repetitive DE-induced bronchioalveolar inflammation or lymphoid aggregate formation. Lung tissue ICAM-1 expression was also reduced in both single and repetitive exposure studies. These data suggest that MaR1 might contribute to an effective strategy to reduce airway inflammatory diseases induced by agricultural-related organic dust environmental exposures. [Description provided by NIOSH]
• Subjects:
  Agriculture Dust Energy Metabolism Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Agricultural-industry Drugs Dust-exposure Dust-particles Etiology Laboratory-animals Lung-disorders Metabolism Organic-dusts Pharmacology Pulmonary-disorders

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• ISSN:
  1931-5244
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Nebraska ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  57-69
• Volume:
  166
• Issue:
  1
• NIOSHTIC Number:
  nn:20046653
• Citation:
  Transl Res 2015 Jul; 166(1):57-69
• Contact Point Address:
  Debra J. Romberger, 983332 Nebraska Medical Center, Omaha, NE 68198-3332
• Email:
  dromberg@unmc.edu
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Nebraska Medical Center, Omaha, Nebraska
• Peer Reviewed:
  True
• Start Date:
  20060801
• Source Full Name:
  Translational Research: the Journal of Laboratory and Clinical Medicine
• End Date:
  20160731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:76744f4132051ff9c8071dfd2d77a6c083ec034f9e7c5b4cbeea6299e3938ec0cb7a930809fafc122a7b45df4f6d5e091d593499af804b0017043db6ffb41207
• Download URL:
  https://stacks.cdc.gov/view/cdc/202014/cdc_202014_DS1.pdf
• File Type:
  [PDF - 2.48 MB ]