Dose- and time-dependent effects of sub-chronic functionalized MWCNT exposure on human mesothelial cell neoplastic transformation potential

Details

• Personal Author:
  Davidson DC ; Derk R ; Gracheck P ; Rojanasakul Y ; Stueckle, Todd A. ; Wang L ; Wu N
• Description:
  Comparative studies evaluating how MWCNT physicochemical properties influence pleural mesothelioma potential are critically needed. We hypothesized that MWCNT surface functionalization would affect human mesothelial cell neoplastic transformation potential in a dose/time dependent manner. Cells were continuously exposed to fully characterized parent(p), two different functionalized (f) MWCNTs, or asbestos (ASB) for 6 months at in vivo-relevant doses. Low dose fMWCNT caused significant cell proliferation increase compared to controls throughout the exposure. pMWCNT, one fMWCNT and ASB cells exhibited significantly greater numbers of soft agar colonies compared to controls, with low dose eliciting a more potent effect. Cells exposed to only one fMWCNT exhibited a significant increase in cell invasion ability. Subchronic in vitro exposure models can assist in screening and prioritizing engineered nanomaterials for in vivo risk and aid occupational-associated disease detection strategies. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Lung Lung Diseases Occupational Health Respiratory System Safety
• Keywords:
  Author Keywords: Carbon Nanotubes Cell-cultures Cell-metabolism Cell Transformation Cellular-reactions Diseases Exposure-levels Functionalization In-vitro-study In-vivo-study In Vitro Model Lung-disorders Lung-tissue Mesothelial-cells Mesothelium Models Nanotechnology Workers

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• ISBN:
  9781498747332
• Publisher:
  CRC Press
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  1
• Issue:
  10
• NIOSHTIC Number:
  nn:20046458
• Citation:
  TechConnect Briefs 2015: Technical Proceedings of the 2015 TechConnect World Innovation Conference & Expo; Volume 1 - Advanced Materials; Session 10 - Soft Matter & Colloids, June 15-18, 2015, Washington, DC. Boca Raton, FL: CRC Press, 2015 Jun; 1(10):574-577
• Email:
  tstueckle@cdc.gov
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  TechConnect Briefs 2015: Technical Proceedings of the 2015 TechConnect World Innovation Conference & Expo; Volume 1 - Advanced Materials; Session 10 - Soft Matter & Colloids, June 15-18, 2015, Washington, DC
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f71dfb02f835f015284cde5a494c81ce92c2cf7eed1cb0eac4f55c696883dd3fd58390c6149c5bf92a48e80f8f20477c04ed1cecd34f6b7a97e495afa765986b
• Download URL:
  https://stacks.cdc.gov/view/cdc/201512/cdc_201512_DS1.pdf
• File Type:
  [PDF - 817.10 KB ]