Systemic inflammation associated with World Trade Center dust exposures and airway abnormalities in the local community

Details

• Personal Author:
  Berger KI ; Caplan Shaw C ; Cheng X ; Chokshi NP ; Fernandez-Beros ME ; Ghumman M ; Goldring RM ; Kazeros A ; Levy-Carrick N ; Liu M ; Marmor M ; Parsia S ; Qian M ; Reibman J ; Shao Y ; Zhang E
• Description:
  Background: Destruction of the World Trade Center (WTC) towers on September 11, 2001, released massive dust, gas, and fumes with environmental exposures for community members. Many community members have lower respiratory symptoms (LRSs) that began after September 11, 2001, and remain persistent. We evaluated whether systemic inflammation measured by C-reactive protein was associated with WTC dust exposures, persistent LRS, and lung function. Methods: Community members self-referred for the treatment of symptoms related to September 11, 2001. C-reactive protein and lung function measurements, including spirometry and forced oscillation tests (impulse oscillometry system), were included as routine analyses in patients (2007 to 2012). Results: Increased C-reactive protein levels were associated with the type of WTC dust exposure, LRS, reduced spirometry, and increased forced oscillation measurements (n = 724). Conclusions: Ongoing systemic inflammation measured years after the event was associated with WTC dust exposures, persistent LRS, and abnormal lung function in a community cohort. These findings have implications for treatment and surveillance. [Description provided by NIOSH]
• Subjects:
  Dust Emergency Responders Environmental Exposure Hazardous Substances Health Care Facilities Workforce And Services Immune System Lung Lung Diseases Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety Smokers Tobacco Products

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• Keywords:
  Airway-obstruction Cigarette-smoking Dose-response Dust-exposure Dust-particles Dusts Emergency-responders Environmental-exposure Hazardous-materials Immune-reaction Immune-system Lung-disorders Lung-function Medical-monitoring Medical-screening Medical-treatment Oscillography Physiological-measurements Proteins Pulmonary-system-disorders Rescue-workers Respiratory-function-tests Respiratory-system-disorders Smoking Spirometry Surveillance-programs

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant ; Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  57
• Issue:
  6
• NIOSHTIC Number:
  nn:20046301
• Citation:
  J Occup Environ Med 2015 Jun; 57(6):610-616
• Contact Point Address:
  Angeliki Kazeros, MD, New York University School of Medicine, 550 1st Ave, Room BH-7N24, New York, NY 10016
• Email:
  angeliki.kazeros@nyumc.org
• Federal Fiscal Year:
  2015
• Performing Organization:
  New York City Health and Hospitals Corporation
• Peer Reviewed:
  True
• Start Date:
  20080929
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20110928
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:22d114a80ba84e0844bb72ea50d3614cff62cd59cd01b3a41a23dc0726f55b7157197d808aa82fa2d7629badbc837589296c700c14dd97e7fea41c4ab32efebc
• Download URL:
  https://stacks.cdc.gov/view/cdc/201403/cdc_201403_DS1.pdf
• File Type:
  [PDF - 188.78 KB ]