GHS classifications for diacetyl, 2,3-pentanedione, and mixtures containing these chemicals

Details

• Personal Author:
  Hubbs A ; Kreiss, Kathleen ; Niemeier R
• Description:
  Situation/Problem: In 2012, OSHA revised the Hazard Communication Standard (HCS) to align with the United Nations Globally Harmonized System for Classification and Labelling (GHS) of chemicals. This revised HCS standard provides criteria for hazard classification, new label elements (pictograms, signal words, hazard statements, and precautionary statements), and a standardized safety data sheet (SDS) format. The previously available GHS classifications for diacetyl and 2,3-pentanedione do not reflect the hazard data available and presented in the soon to be finalized NIOSH criteria document, Occupational Exposure to Diacetyl and 2,3-Pentanedione. Resolution: Using the criteria outlined in the HCS, NIOSH has provided, for the first time for any substances, GHS classifications for diacetyl and 2,3-pentanedione. These classifications were based on the human health and animal toxicology data, and exposure monitoring data provided in the criteria document. Importantly, NIOSH also provided guidance for the classification and labeling of mixtures containing diacetyl and 2,3-pentanedione. Draft GHS classifications were published for peer and public review in early 2014. Results: Several GHS classifications were proposed for these chemicals, and NIOSH also demonstrated that exposures over the recommended exposure limits (RELs) for these chemicals could still occur if the cut-off values for mixtures in the GHS criteria were applied. NIOSH recommended that mixtures containing diacetyl or 2,3-pentanedione at any concentration that could generate vapors exceeding the NIOSH RELs should provide the necessary classifications on product labels and SDSs. Lessons Learned: GHS classifications that represent the current scientific understand of diacetyl and 2,3-pentanedione are important for the health protection of flavoring manufacturing workers. In addition, the incorporation of occupational exposure data should be considered when determining GHS classifications for hazardous chemicals that are present in mixtures. In the case of diacetyl and 2,3-pentanedione, the sole reliance on prescribed cut-off values for hazardous chemicals in mixtures would not have provided hazard communication guidance that was health protective for workers. [Description provided by NIOSH]
• Subjects:
  Chemistry Communications Media Environmental Monitoring Food Additives Hazardous Substances Occupational Health Safety
• Keywords:
  Chemical-analysis Chemical-composition Chemical-properties Chemical-structure Communication-systems Exposure-assessment Exposure-limits Food-additives Hazardous-materials Information-processing Information-systems Safety-education Signaling-systems Standards Toxic-effects Toxic-materials Warning-systems

  More +
• Publisher:
  American Industrial Hygiene Association
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 8 ; Utah ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division ; HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  86
• NIOSHTIC Number:
  nn:20046282
• Citation:
  AIHce 2015: American Industrial Hygiene Conference and Exposition, May 30 - June 4, 2015, Salt Lake City, Utah. Falls Church, VA: American Industrial Hygiene Association, 2015 May; :86
• CAS Registry Number:
  2,3-Pentanedione (CAS RN 600-14-6) ; Butanedione (CAS RN 431-03-8)
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  AIHce 2015: American Industrial Hygiene Conference and Exposition, May 30 - June 4, 2015, Salt Lake City, Utah
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e58d59f34ec126d0d758349141a7658dfbd269ab013db206f4ec2829b685351aa9940fcf2096f9df83a6c8d9166c53c0d5a47e0cde38b742a8306f8488873a0f
• Download URL:
  https://stacks.cdc.gov/view/cdc/201386/cdc_201386_DS1.pdf
• File Type:
  [PDF - 685.82 KB ]