Silicosis and chronic renal disease

Details

• Personal Author:
  Millerick-May ML ; Reilly MJ ; Rosenman, Kenneth D. ; Schrauben S
• Description:
  Background: Silica has been associated with end stage kidney disease and kidney dysfunction. Methods: Calculated glomerular filtration rate, history of kidney disease or chronic dialysis, elevated serum creatinine, and stages of chronic kidney disease among silicotics identified in Michigan's Silicosis Surveillance System from 1987 to 2009 were reviewed to determine the prevalence of kidney disease in confirmed cases of silicosis. Results: Twenty-four percent of 1,072 silicotics had a measure of kidney dysfunction (32.3% if diabetes or hypertension present vs. 20.2% if not). Sixty-nine percent of silicotics had Stage I or greater chronic kidney dysfunction versus 38.8% of the U.S. general population 60 years. No association was found between kidney function and measures of silica exposure. Conclusions: Individuals with silicosis have an increased prevalence of kidney disease. More work to define the pathological changes associated with silica exposure is needed to understand the cause of silica's adverse effect on the kidney. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Kidney Diseases Occupational Health Safety Silicon Dioxide Silicosis Urogenital Diseases Urogenital System
• Keywords:
  Author Keywords: Silicosis Diseases Kidney-damage Kidney-disorders Kidney-function Kidneys Renal Disease Silica Silicates Statistical-analysis
• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  7
• NIOSHTIC Number:
  nn:20046151
• Citation:
  Am J Ind Med 2015 Jul; 58(7):730-736
• Contact Point Address:
  Melissa L. Millerick-May, MS, PhD, Department of Medicine, College of Human Medicine, Michigan State University, 909 Fee Rd. Room 120 West Fee Hall, East Lansing, MI 48824
• Email:
  melissa.may@hc.msu.edu
• CAS Registry Number:
  Silica (CAS RN 7631-86-9)
• Federal Fiscal Year:
  2015
• Performing Organization:
  Michigan State University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d6104a8539eadc26297e8c03d55090ac124953ac78e3b0a2a21932143c1e9023128a917edf71add3c77735c32a74dab9381f865d4b2a39a2821a3912e379acb
• Download URL:
  https://stacks.cdc.gov/view/cdc/201285/cdc_201285_DS1.pdf
• File Type:
  [PDF - 92.94 KB ]