Skin permeability of ortho-phenylphenol in metalworking formulations

Details

• Personal Author:
  Baynes RE ; Brooks J ; Haegele T ; Kochenburger J
• Description:
  Over 10 million workers worldwide are exposed to metal working fluids (MWF). Phenols are common constituents of MWF's and have been known to cause irritant contact dermatitis in humans. This study assessed the in vitro dermal absorption of [14C]-radiolabeled ortho-phenylphenol (OPP). Twenty-eight porcine skin sections from the dorsum of an adult pig were used in a flow-through diffusion cell system. A dosing solution of [14C]-radiolabeled OPP in water, water + 5% soluble oil, 5% semi-synthetic, or 5% synthetic MWF was applied to each skin surface (n=7 each). Timed perfusate samples were collected for 24 hours and the level of [14C]-radiolabeled OPP was measured via liquid scintillation counting. At termination, mass balance samples were taken of the skin sample, stratum corneum, surface swabs, dosing device and the remaining dose left on the skin's surface. OPP is a lipophillic compound (log Ko/w= 3.09) and it was expected to permeate the skin at its highest levels in the water, then the synthetic oil, followed by the semi-synthetic oil, and least in the soluble oil. Data analysis showed that the log permeability (logKp) values were -1.70 cm/h for water, -2.20 cm/h for synthetic oil, -2.62 cm/h for semi-synthetic oil, and -2.76 cm/h for soluble oil. This indicates that the safest way to use OPP in MWF's is in a semi-synthetic oil solution or soluble oil solution to minimize dermal absorption in the workplace. Other related in vitro and in vivo studies in the near future will make it possible to estimate in vivo dermal absorption in human skin for various MWF formulations. This information can then be used to help formulate and regulate occupational safety rules to benefit those working with MWF's. [Description provided by NIOSH]
• Subjects:
  Dermatitis Environmental Monitoring Laboratories Metals Occupational Health Phenol Safety Skin Skin Absorption Toxicology
• Keywords:
  Contact-dermatitis Exposure-assessment In-vitro-study Laboratory-animals Laboratory-techniques Laboratory-testing Metalworking-fluids Oils Phenols Phenyls Scintillation-counters Skin-absorption Skin-exposure Skin-irritants Skin-tests Synthetics

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• ISSN:
  1096-6080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; North Carolina ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  144
• Issue:
  1
• NIOSHTIC Number:
  nn:20046043
• Citation:
  Toxicologist 2015 Mar; 144(1):271
• CAS Registry Number:
  [1,1′-Biphenyl]-2-ol (CAS RN 90-43-7)
• Federal Fiscal Year:
  2015
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  False
• Start Date:
  20000801
• Source Full Name:
  The Toxicologist. Society of Toxicology 54th Annual Meeting and ToxExpo, March 22-26, 2015, San Diego, California
• End Date:
  20150731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:92210819ebef81fafef3c0ae03fb63b17c9ef3aaa0652892cbf7458c4f8775fa086b6e39fcdd17ee608f6aa55221e3e449b400c6f66118c04c20d0b18d6cd26f
• Download URL:
  https://stacks.cdc.gov/view/cdc/201227/cdc_201227_DS1.pdf
• File Type:
  [PDF - 1.07 MB ]