Prepubertal organochlorine pesticide concentrations and age of pubertal onset among Russian boys

Details

• Personal Author:
  Altshul LM ; Birnbaum LS ; Burns JS ; Hauser R ; Korrick SA ; Lam T ; Lee MM ; Patterson DG Jr. ; Revich B ; Sergeyev O ; Turner, Wayman E. ; Williams PL
• Description:
  BACKGROUND: In animal studies, organochlorine pesticide (OCP) exposure alters pubertal development; however, epidemiological data are limited and inconsistent. OBJECTIVE: To evaluate the associations of serum OCP concentrations [hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE)] with male pubertal onset. METHODS: In Chapaevsk, Russia, a town environmentally contaminated with OCPs, 350 8-9 year old boys with measured OCPs were enrolled during 2003-2005 and were followed annually for eight years. We evaluated three measures of pubertal onset: testicular volume (TV)>3 mL in either testis, or stage 2 or greater for genitalia (G2+), or pubic hair (P2+). We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with physician-assessed pubertal onset. RESULTS: In adjusted models, boys with higher HCB concentrations had later mean ages of TV>3 mL and P2+ (but not G2+). Mean age at attaining TV>3 mL was delayed 3.6 (95% CI: -2.6, 9.7), 7.9 (95% CI: 1.7, 14.0), and 4.7 months (95% CI: -1.4, 10.9) for HCB Q2, Q3, and Q4, respectively, compared to Q1 (trend p: 0.06). Boys with higher HCB concentrations reached P2+ 0.1 months earlier (95% CI: -5.8, 5.6) for Q2, 4.7 months later (95% CI: -1.0, 10.3) for Q3 and 4.6 months later (95% CI: -1.1, 10.3) for Q4 compared to Q1 (trend p: 0.04). There were no associations of serum beta-HCH and p,p'-DDE concentrations with age of pubertal onset. CONCLUSION: Higher prepubertal serum HCB concentrations were associated with later age of gonadarche and pubarche. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Environmental Pollution Epidemiology Insecticides Occupational Health Safety
• Keywords:
  Author Keywords: HCB Beta-HCH Children Environmental Hazards Male Puberty Organo-chlorine Compounds Organochlorine Pesticides P,p'-DDE Pesticides
• ISSN:
  0160-4120
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; North Carolina ; OSHA Region 1 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  135-142
• Volume:
  73
• NIOSHTIC Number:
  nn:20045499
• Citation:
  Environ Int 2014 Dec; 73:135-142
• CAS Registry Number:
  Cyclohexane, 1,2,3,4,5,6-hexachloro- (CAS RN 608-73-1) ; Hexachlorobenzene (CAS RN 118-74-1) ; p,p′-DDE (CAS RN 72-55-9)
• Federal Fiscal Year:
  2015
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environment International
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c2bdc421532810bf5116c9a53687edceaa86bd81094d0d6a0c18b2f992d9bccdf2487927025fb48e4b05d5d93aceecc1681b01c2471f5f44030573d06fc0cf7c
• Download URL:
  https://stacks.cdc.gov/view/cdc/200899/cdc_200899_DS1.pdf
• File Type:
  [PDF - 385.23 KB ]