Cardiolipin asymmetry, oxidation and signaling

Details

• Personal Author:
  Bayir H ; Cheikhi A ; Chu CT ; Kagan VE ; Tyurina YY
• Description:
  Cardiolipins (CLs) are ancient and unusual dimeric phospholipids localized in the plasma membrane of bacteria and in the inner mitochondrial membrane of eukaryotes. In mitochondria, two types of asymmetries--trans-membrane and molecular--are essential determinants of CL functions. In this review, we describe CL-based signaling mitochondrial pathways realized via modulation of trans-membrane asymmetry and leading to externalization and peroxidation of CLs in mitophagy and apoptosis, respectively. We discuss possible mechanisms of CL translocations from the inner leaflet of the inner to the outer leaflet of the outer mitochondrial membranes. We present redox reaction mechanisms of cytochrome c-catalyzed CL peroxidation as a required stage in the execution of apoptosis. We also emphasize the significance of CL-related metabolic pathways as new targets for drug discovery. Finally, a remarkable diversity of polyunsaturated CL species and their oxidation products have evolved in eukaryotes vs. prokaryotes. This diversity--associated with CL molecular asymmetry--is presented as the basis for mitochondrial communications language. [Description provided by NIOSH]
• Subjects:
  Coal Coal Mining Dust Explosions Mining Occupational Health Safety
• Keywords:
  Apoptosis Author Keywords: Cardiolipin Bacteria Biological-function Cardiolipin Asymmetry Cardiolipin Oxidation Mitochondria Mammalian-cells Mitophagy Molecular-structure Oxidation Phospholipids Plasma-membrane

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• ISSN:
  0009-3084
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  64-69
• Volume:
  179
• NIOSHTIC Number:
  nn:20045289
• Citation:
  Chem Phys Lipids 2014 Apr; 179:64-69
• Contact Point Address:
  Valerian E. Kagan, Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Bridgeside Point, 100 Technology Drive, Suite 350, Pittsburgh, PA 15219
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Pittsburgh at Pittsburgh
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Chemistry and Physics of Lipids
• End Date:
  20160630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:920f0fe36af5fa0724b9ad623192d3e7ed559280152a81a1d67192f3fea5497beecbc0e41e63dc09101c86f8dd1ab2f63d041af91cd942c6bc3308d44c92ea19
• Download URL:
  https://stacks.cdc.gov/view/cdc/200754/cdc_200754_DS1.pdf
• File Type:
  [PDF - 921.49 KB ]