In vivo processing of ceria nanoparticles inside liver: impact on free-radical scavenging activity and oxidative stress

Details

• Personal Author:
  Butterfield DA ; Davis BH ; Dozier, Alan K. ; Graham UM ; Grulke EA ; Hardas SS ; Jasinski JB ; Sultana R ; Tseng MT ; Unrine JM ; Yokel RA
• Description:
  The cytotoxicity of ceria ultimately lies in its electronic structure, which is defined by the crystal structure, composition, and size. Despite previous studies focused on ceria uptake, distribution, biopersistance, and cellular effects, little is known about its chemical and structural stability and solubility once sequestered inside the liver. Mechanisms will be presented that elucidate the in vivo transformation in the liver. In vivo processed ceria reveals a particle-size effect towards the formation of ultrafines, which represent a second generation of ceria. A measurable change in the valence reduction of the second-generation ceria can be linked to an increased free-radical scavenging potential. The in vivo processing of the ceria nanoparticles in the liver occurs in temporal relation to the brain cellular and protein clearance responses that stem from the ceria uptake. This information is critical to establish a possible link between cellular processes and the observed in vivo transformation of ceria. The temporal linkage between the reversal of the pro-oxidant effect (brain) and ceria transformation (liver) suggests a cause-effect relationship. [Description provided by NIOSH]
• Subjects:
  Chemistry Cytotoxins Free Radicals Nervous System Occupational Health Particulate Matter Safety
• Keywords:
  Author Keywords: Biotransformations Biotransformation Brain-function Cellular-function Cellular-reactions Cellular Chemistry Cerium Cerium-compounds Chemical-reactions Chemical-structure Crystal-structure Cytotoxicity Free-radicals In-vivo-study Liver Liver-cells Nanoparticles Nanotechnology Oxidation-reduction-reactions Oxidative-processes Particulates Redox Chemistry

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• ISSN:
  2192-6506
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  79
• Issue:
  8
• NIOSHTIC Number:
  nn:20045022
• Citation:
  ChemPlusChem 2014 Aug; 79(8):1083-1088
• Contact Point Address:
  Dr. U. M. Graham, Center for Applied Energy Research and Catalysis Research and Testing Center, University of Kentucky, 2540 Research Park Drive, Lexington, KY 40511 USA
• Email:
  graham@liquasol.com
• CAS Registry Number:
  Ceria (CAS RN 1306-38-3)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  ChemPlusChem
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:16d8b5a238d7e24c91e2360dfe496e5ea830379396da0e7a7276ee772d119ad3adf80790dea853393072ec0963fb2a89a164b34265f3184dc84eedd3ce12b916
• Download URL:
  https://stacks.cdc.gov/view/cdc/200574/cdc_200574_DS1.pdf
• File Type:
  [PDF - 1.17 MB ]