Human and animal evidence supports lower occupational exposure limits for poorly-soluble respirable particles. Letter to the editor re: 'Low-toxicity dusts: current exposure guidelines are not sufficiently protective' by Cherrie, Brosseau, Hay and Donaldson

Details

• Personal Author:
  Attfield MD ; Castranova, Vincent ; Kuempel, Eileen D. ; Stayner, Leslie T.
• Description:
  We commend the overall evaluation by Cherrie et al. (2013) of the current occupational exposure limits (OELs) for respirable poorly-soluble low toxicity (PSLT) particles. As described in that paper, the epidemiological studies provide compelling evidence that exposure to PSLT at the current OELs has been associated with adverse health effects, including pulmonary fibrosis and lung function deficits. In contrast to Cherrie et al. (2013), we discuss here that the chronic inhalation studies in animals also provide evidence of the adverse pulmonary effects of PSLT. Cherrie et al. view has been accepted by some regulatory institutions. For example, in the USA, the regulatory exposure limit for respirable coal mine dust is to be reduced from 2 mg m-3 as a multi-shift average concentration to 1.5 mg m-3 as a single-shift (8-hr time-weighted average) concentration, starting in August 2016 (MSHA, 2014). In addition, the rat studies provide supporting evidence with qualitatively and quantitatively consistent findings to those in the human studies. Yet, more research is needed to reduce uncertainty about the rodent dose-response models compared to humans. Such evidence is important for risk assessment and OEL development of other types of airborne particles (e.g., nanoparticles) for which sufficient human data may not be available. [Description provided by NIOSH]
• Subjects:
  Chronic Disease Dust Epidemiology Hazardous Substances Laboratories Lung Diseases Occupational Exposure Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Toxicology

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• Keywords:
  Chronic-exposure Chronic-inflammation Dose-response Exposure-limits Health-hazards Humans Inhalation-studies Laboratory-animals Lung-disorders Occupational-exposure Particulates Permissible-concentration-limits Pulmonary-system-disorders Respirable-dust Respiratory-system-disorders Surveillance

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• ISSN:
  0003-4878
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division ; DRDS - Division of Respiratory Disease Studies ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  9
• NIOSHTIC Number:
  nn:20045011
• Citation:
  Ann Occup Hyg 2014 Nov; 58(9):1205-1208
• Contact Point Address:
  Eileen D. Kuemple, National Institute for Occupational Safety and Health, Education and Information Division, 1090 Tusculum Avenue, Cincinnati, OH, 45226 USA
• Email:
  ekuempel@cdc.gov
• Federal Fiscal Year:
  2015
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Occupational Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:73072c06f75b2e76e58c763f77fbc46ab5bb894e02c71f8cd2f71fa507f6f652974b33f78d945199c84ab11824742884846b42e32e30c9f91966c07fae6af65e
• Download URL:
  https://stacks.cdc.gov/view/cdc/200567/cdc_200567_DS1.pdf
• File Type:
  [PDF - 483.64 KB ]