Use of contrast-enhanced sonography to investigate intraneural vascularity in a cohort of Macaca fascicularis with suspected median mononeuropathy

Details

• Personal Author:
  Buford J ; Evans KD ; Fout LT ; Pargeon RL ; Roll SC ; Volz KR
• Description:
  Objectives: The purpose of this study was to provide clinical evidence of the use of contrastenhanced sonography in detecting and quantifying changes in intraneural vascularity due to median mononeuropathy. Methods: Five Macaca fascicularis monkeys were exposed to 20 weeks of repetitive work to increase their risk of developing median mononeuropathy. Contrast-enhanced sonograms were obtained in 30-second increments for 7 minutes while a contrast agent was being delivered. Data were collected immediately at the conclusion of the 20-week work exposure and then again during a recovery phase approximately 3 months after the completion of work. Quantitative analysis and trend graphs were used to analyze median nerve perfusion intensity. This study also compared the use of both manual counting of pixels and semiautomatic measurement using specialized software. Results: Based on the average data, maximum intensity values were identified as the best indicators of nerve hyperemia. Paired t tests demonstrated significantly higher maximum intensities in the working stage for 4 of the 5 subjects (P < .01). Conclusions: This study provides preliminary evidence that (1) in a controlled exposure model, a change in intraneural vascularity of the median nerve between working and recovery can be observed; (2) this vascular change can be measured using an objective technique that quantifies the intensity of vascularity; and (3) contrast-enhanced sonography may improve the ability to reliably capture and measure low-flow microvascularity. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Musculoskeletal Diseases Musculoskeletal System Nervous System Nervous System Diseases Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Carpal Tunnel Syndrome Carpal-tunnel-syndrome Contrast-enhanced Sonography Exposure-levels Laboratory-animals Median Mononeuropathy Musculoskeletal-system Musculoskeletal-system-disorders Musculoskeletal Ultrasound Nerve-function Nerves Neuromuscular-function Neuromuscular-system Neuromuscular-system-disorders Neuropathy Repetitive-work Risk-factors Ultrasound

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• ISSN:
  0278-4297
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  103-109
• Volume:
  33
• Issue:
  1
• NIOSHTIC Number:
  nn:20044998
• Citation:
  J Ultrasound Med 2014 Jan; 33(1):103-109
• Contact Point Address:
  Kevin D. Evans, PhD, RT, RDMS, RVS, The Ohio State University, 453 W 10th Ave, Columbus, OH 43210
• Email:
  evans.36@osu.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20100901
• Source Full Name:
  Journal of Ultrasound in Medicine
• End Date:
  20130430
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9f33e1c161d5e706efb92b7fa1f0a701cb244869c73df3f6d106b068216059c5f487a61915fd7675d506e6b15bc7d6598833727cdd5ba1ae4188360394c99eef
• Download URL:
  https://stacks.cdc.gov/view/cdc/200559/cdc_200559_DS1.pdf
• File Type:
  [PDF - 408.18 KB ]