Differences in estimates of beryllium aerosol size distribution for toxicity studies using phase contrast microscopy, scanning electron microscopy, and liquid particle counter techniques

Details

• Personal Author:
  Breysse PN ; Day, Gregory A. ; Hoover, Mark D. ; Scripsick RC ; Stefaniak, Aleksandr B.
• Description:
  Relating the physicochemical properties of an aerosol to its toxicity following inhalation is of specific interest for beryllium (Stefaniak et aI., 2004) as well as of general interest for a wide range of particles, e.g., nanomaterials (Oberdorster et aI., 2005). Various hypotheses have been put forth regarding particle mass, surface area, and number as metrics of toxicity of inhaled particles. Detailed control and physicochemical characterization of aerosols generated for inhalation toxicology studies is essential for obtaining meaningful study results. A high priority of research is characterization of the exposure material as encountered by workers and as administered in an inhalation toxicology study. Characterization of bulk material as produced or supplied may not accurately reflect the properties of the particles in the workplace atmosphere or delivered by inhalation, installation, or pharyngeal aspiration to laboratory animals. For example, current methods for characterizing dry material using microscopy can reveal general morphology and particle size, but are not capable of determining whether material consists of solid particles or clusters, or whether material will deagglomerate in lung surfactant. Similarly, current methods for characterizing material in suspension can reveal "equivalent" particle diameter, but are not capable of determining particle morphology. Thus a suite of techniques are needed to understand the multiple particle properties that may influence toxicity. The purpose of this study was to characterize the morphology and investigate the size distributions of four beryllium materials using thre" standard sizing techniques as they may reveal important characteristics of the study material. [Description provided by NIOSH]
• Subjects:
  Aerosols Animals Chemistry Hazardous Substances Laboratories Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Toxicology Workplace

  More +
• Keywords:
  Aerosol-particles Author Keywords: Aerosol Generation Chemical-properties Exposure-levels Laboratory-animals Lung-function Lung-irritants Lung-tissue Nanotechnology Particulates Pulmonary-disorders Pulmonary-function Pulmonary-system Pulmonary-system-disorders Respiration Respiratory Deposition Risk-factors Toxic-effects Toxins Work-environment Workers

  More +
• ISBN:
  9780978873509
• Publisher:
  American Association for Aerosol Research
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; New Mexico ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20044867
• Citation:
  Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota. Biswas P, Chen DR, Hering S, eds. Mount Laurel, NJ: American Association for Aerosol Research, 2006 Sep; :928-929
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7)
• Editor(s):
  Biswas P; Chen DR; Hering S
• Federal Fiscal Year:
  2006
• Performing Organization:
  Johns Hopkins University, Baltimore, Maryland
• Peer Reviewed:
  False
• Start Date:
  20010601
• Source Full Name:
  Proceedings of the Seventh International Aerosol Conference, September 10-15, 2006, St. Paul, Minnesota
• End Date:
  20040531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:76c451ce435604ce0d74dd188a73715b3c0b39df80d07162379688a65389994393d3f00543b2681f8d8584a7e3e444cfe97fbf3d1a7310368ba3d9c8124d17b0
• Download URL:
  https://stacks.cdc.gov/view/cdc/200476/cdc_200476_DS1.pdf
• File Type:
  [PDF - 2.00 MB ]