Antimicrobial activity and biocompatibility of polyurethane--iodine complexes

Details

• Personal Author:
  Deng Y ; Luo J ; Sun Y
• Description:
  Polyurethane (PU), one of the most versatile biomedical materials, strongly binds iodine, one of the most effective antiseptics, through the formation of a charge-transfer complex. The PU-Iodine complexes were characterized with UV/Vis study and X-ray photoelectron spectroscopy (XPS) analysis. The new materials evoked potent antimicrobial activity against Gram-negative and Gram-positive bacteria (including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and bacterial spores), fungi, and viruses, as well as inhibited surface bacterial colonization and biofilm-formation. Based on the Kirby-Bauer test, the antimicrobial effects occurred through the slow release of iodine. The iodine release rate can be controlled by the preparation conditions of the PU-Iodine complex. Trypan blue exclusion analysis indicated that PU-Iodine has excellent mammalian cell viability. The PU-Iodine complexes have the potential for a wide range of medical, dental, and other related applications. [Description provided by NIOSH]
• Subjects:
  Bacterial Infections Microbiology Occupational Health Safety
• Keywords:
  Antibacterial Antiinfective Antimicrobial Author Keywords: Polyurethane Bacteria Bacterial-disease Bacterial-infections Bactericides Biocompatible Biofilm-controlling Controlled Iodine Release Iodine Iodine Release Microorganisms

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• ISSN:
  0883-9115
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 8 ; South Dakota
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  185-206
• Volume:
  25
• Issue:
  2
• NIOSHTIC Number:
  nn:20044856
• Citation:
  J Bioact Compat Polym 2010 Mar; 25(2):185-206
• Contact Point Address:
  Yuyu Sun, Biomedical Engineering Program, University of South Dakota, Vermillion, South Dakota 57107, USA
• Email:
  yuyu.sun@usd.edu
• CAS Registry Number:
  Iodine (CAS RN 7553-56-2)
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of South Dakota
• Peer Reviewed:
  True
• Start Date:
  20080601
• Source Full Name:
  Journal of Bioactive and Compatible Polymers
• End Date:
  20110531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:06141d0a271910f8ea4ad4288f607539390935b4c2227f16d661a481cef7038115cc6d8129e220c51d890c224d630696fca853b24b1ff24b7f39e321f276cb6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/200468/cdc_200468_DS1.pdf
• File Type:
  [PDF - 332.28 KB ]