Recovery of vascular function after exposure to a single bout of segmental vibration

Details

• Personal Author:
  Johnson C ; Krajnak, Kristine M. ; Miller, G. Roger ; Waugh, Stacey
• Description:
  Work rotation schedules may be used to reduce the negative effects of vibration on vascular function. This study determined how long it takes vascular function to recover after a single exposure to vibration in rats (125 Hz, acceleration 5g). The responsiveness of rat-tail arteries to the vasoconstricting factor UK14304, an á2C-adrenoreceptor agonist, and the vasodilating factor acetylcholine (ACh) were measured ex vivo 1, 2, 7, or 9 d after exposure to a single bout of vibration. Vasoconstriction induced by UK14304 returned to control levels after 1 d of recovery. However, re-dilation induced by ACh did not return to baseline until after 9 d of recovery. Exposure to vibration exerted prolonged effects on peripheral vascular function, and altered vascular responses to a subsequent exposure. To optimize the positive results of work rotation schedules, it is suggested that studies assessing recovery of vascular function after exposure to a single bout of vibration be performed in humans. [Description provided by NIOSH]
• Subjects:
  Biological Factors Biomechanical Phenomena Environmental Monitoring Laboratories Occupational Health Risk Assessment Risk Factors Safety Vibration
• Keywords:
  Biological-effects Biological-factors Biological-monitoring Biomechanical-modeling Biomechanics Exposure-assessment Exposure-levels Hand-tools Injury-prevention Laboratory-animals Laboratory-techniques Mathematical-models Measurement-equipment Physiological-effects Physiological-response Quantitative-analysis Repetitive-work Risk-factors Statistical-analysis Tools Vasomotor-system Vasomotor-system-disorders Vibration-effects Vibration-exposure

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• ISSN:
  1528-7394
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  77
• Issue:
  17
• NIOSHTIC Number:
  nn:20044775
• Citation:
  J Toxicol Environ Health A 2014 Sep; 77(17):1061-1069
• Contact Point Address:
  Kristine Krajnak, Ph.D, NIOSH, 1095 Willowdale Rd, MS2027, Morgantown, WV 26505
• Email:
  ksk1@cdc.gov
• Federal Fiscal Year:
  2014
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Toxicology and Environmental Health, Part A: Current Issues
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e421ebd5c5694f8b6a5114a2c25b01780f869bc6e2c01f2cf7c4230251327a6042bd3bdf45bf55cc262c567087f9e8ff04b3e73533219c5a7443c517cb152e84
• Download URL:
  https://stacks.cdc.gov/view/cdc/200408/cdc_200408_DS1.pdf
• File Type:
  [PDF - 461.71 KB ]