Association of short-term increases in ambient air pollution and timing of initial asthma diagnosis among Medicaid-enrolled children in a metropolitan area

Details

• Personal Author:
  Chan W ; Du XL ; Stock TH ; Symanski, Elaine ; Wendt JK
• Description:
  OBJECTIVE: We investigated associations of short-term changes in ambient ozone (O3), fine particulate matter (PM2.5) and nitrogen dioxide (NO2) concentrations and the timing of new-onset asthma, using a large, high-risk population in an area with historically high ozone levels. METHODS: The study population included 18,289 incident asthma cases identified among Medicaid-enrolled children in Harris County Texas between 2005-2007, using Medicaid Analytic Extract enrollment and claims files. We used a time-stratified case-crossover design and conditional logistic regression to assess the effect of increased short-term pollutant concentrations on the timing of asthma onset. RESULTS: Each 10 ppb increase in ozone was significantly associated with new-onset asthma during the warm season (May-October), with the strongest association seen when a 6-day cumulative average period was used as the exposure metric (odds ratio [OR]=1.05, 95% confidence interval [CI], 1.02-1.08). Similar results were seen for NO2 and PM2.5 (OR=1.07, 95% CI, 1.03-1.11 and OR=1.12, 95% CI, 1.03-1.22, respectively), and PM2.5 also had significant effects in the cold season (November-April), 5-day cumulative lag (OR=1.11. 95% CI, 1.00-1.22). Significantly increased ORs for O3 and NO2 during the warm season persisted in co-pollutant models including PM2.5. Race and age at diagnosis modified associations between ozone and onset of asthma. CONCLUSION: Our results indicate that among children in this low-income urban population who developed asthma, their initial date of diagnosis was more likely to occur following periods of higher short-term ambient pollutant levels. [Description provided by NIOSH]
• Subjects:
  Age Factors Asthma Asthma, Occupational Environmental Exposure Environmental Pollution Occupational Health Particulate Matter Race Factors Safety
• Keywords:
  Age-factors Author Keywords: Air Pollution Bronchial-asthma Child Children Environmental-pollution Exposure-levels Humans Incidence Medicaid Nitrogen-dioxides Particulates Pollutants Racial-factors Seasonal-factors Statistical-analysis

  More +
• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  50-58
• Volume:
  131
• NIOSHTIC Number:
  nn:20044634
• Citation:
  Environ Res 2014 May; 131:50-58
• Contact Point Address:
  Elaine Symanski, University of Texas School of Public Health, 1200 Herman Pressler Dr., RASW 1028, Houston, TX 77030
• Email:
  Elaine.Symanski@uth.tmc.edu
• CAS Registry Number:
  Nitrogen dioxide (CAS RN 10102-44-0)
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:15fe5130c360e1887803b35e7951a8e082c31895cace45475c328bd39397fa5d13b0b1c0537c832a92780c39078e4013a8d0934c834922e28c3b0b966b4bf8fa
• Download URL:
  https://stacks.cdc.gov/view/cdc/200300/cdc_200300_DS1.pdf
• File Type:
  [PDF - 745.64 KB ]