Inverse association between toenail arsenic and body mass index in a population of welders

Details

• Personal Author:
  Cavallari JM ; Christiani, David C. ; Fang SC ; Grashow R ; Kile ML ; Weisskopf MG ; Zhang J
• Description:
  Recent data show that arsenic may play a role in obesity-related diseases. However, urinary arsenic studies report an inverse association between arsenic level and body mass index (BMI). We explored whether toenail arsenic, a long-term exposure measure, was associated with BMI in 74 welders with known arsenic exposure. BMI showed significant inverse associations with toenail arsenic (p=0.01), which persisted in models adjusted for demographics, diet and work history. It is unclear whether low arsenic biomarker concentrations in high BMI subjects truly reflect lower exposures, or instead reflect internal or metabolic changes that alter arsenic metabolism and tissue deposition. [Description provided by NIOSH]
• Subjects:
  Arsenic Biomarkers Body Weight Demography Energy Metabolism Inorganic Chemicals Men Metals Occupational Health Risk Assessment Risk Factors Safety Urine Welding Women

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• Keywords:
  Arsenic-compounds Author Keywords: Arsenic BMI Body-weight Demographic-characteristics Exposure-levels Humans Metabolic-rate Metabolism Models Occupational Health Risk-factors Toenail Urinalysis Weight-factors Welders Welding Fume

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Connecticut ; Maryland ; Massachusetts ; Oregon ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  131-133
• Volume:
  131
• NIOSHTIC Number:
  nn:20044633
• Citation:
  Environ Res 2014 May; 131:131-133
• Contact Point Address:
  Rachel Grashow, Department of Environmental Health, Harvard School of Public Health, Landmark Center, 401 Park Drive, 3rd Floor, Boston, MA 02215
• Email:
  rgrashow@hsph.harvard.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Construction
• Performing Organization:
  CPWR - The Center for Construction Research and Training, Silver Spring, Maryland
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Environmental Research
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f8c49ca28384f4ba25e888f2e69fb0b5fa849b5b1c297d6fb0bd5318ad828bd766892ed8998e5c0cbbcc3e7519259da56c00ab0c61cab0398f7ea625cec7a8cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/200299/cdc_200299_DS1.pdf
• File Type:
  [PDF - 209.46 KB ]