Occupational use of insecticides, fungicides and fumigants and risk of non-Hodgkin lymphoma and multiple myeloma in the Agricultural Health Study

Details

• Personal Author:
  Alavanja M ; Andreotti G ; Barker J ; Barry K ; Beane Freemen L ; Blair, Austin ; Buckman D ; Hines C ; Hofmann J ; Hoppin J ; Koutros S ; Lubin J ; Lynch C ; Sandler D ; Thomas K
• Description:
  Objectives: Farming and exposure to pesticides have been linked to non-Hodgkin lymphoma (NHL), and multiple myeloma (MM) in previous studies. We evaluated use of insecticides, fungicides and fumigants and risk of NHL, including MM and other NHL sub-types in the Agricultural Health Study, a US-based prospective cohort study. Method: A total of 527 cases occurred among 55 875 pesticide applicators from enrollment (1993-1997) through 2011 in Iowa and 2010 in North Carolina. Information on pesticide use, other agricultural exposures and other factors was obtained from questionnaires at enrollment and follow-up approximately five years later (1999-2005). Information from these questionnaires was used to create lifetime-days and intensity- weighted lifetime-days of pesticide use. Poisson regression and polytomous logit models were used to calculate relative risks (RR) and 95% confidence intervals (CI) to evaluate associations between 26 pesticides and NHL and five NHL-subtypes including multiple myeloma, while adjusting for potential confounding factors. Results: Statistically significant positive exposure-response trends occurred between overall NHL risk and lindane (p-trend = 0.004) and DDT (p-trend = 0.02). In addition, ever use of terbufos was associated with NHL overall (RR=1.2; CI=1.0-1.5), but with no exposure-response trend. In sub-type analyses, terbufos and DDT were associated with small cell lymphoma/ chronic lymphocytic leukaemia/marginal cell lymphoma. In addition, lindane and diazinon were associated with follicular lymphoma and permethrin with MM although tests of homogeneity did not show significant differences in exposure-response among NHL-subtypes for any chemical. Conclusions: These findings are among the first to suggest links between DDT, lindane, permethrin, diazinon and terbufos and specific NHL subtypes. [Description provided by NIOSH]
• Subjects:
  Agriculture Carcinogens Chemistry Farmers Fungi Fungicide, Industrial Hypersensitivity Insecticides Irritants Men Occupational Health Risk Assessment Risk Factors Safety Skin Surveys And Questionnaires Women

  More +
• Keywords:
  Agricultural-industry Chemical-composition Chemical-properties Chemical-reactions Exposure-levels Fumigants Fungicides Humans Pesticides Questionnaires Risk-factors Sensitization

  More +
• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Illinois ; Iowa ; Maryland ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  71
• NIOSHTIC Number:
  nn:20044595
• Citation:
  Occup Environ Med 2014 Jun; 71(Suppl 1):A36
• CAS Registry Number:
  DDT (CAS RN 50-29-3) ; Diazinon (CAS RN 333-41-5) ; Lindane (CAS RN 58-89-9) ; Permethrin (CAS RN 52645-53-1) ; Terbufos (CAS RN 13071-79-9)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Peer Reviewed:
  False
• Source Full Name:
  Occupational and Environmental Medicine. Challenges for Occupational Epidemiology in the 21st Century, EPICOH 2014, June 24-27, 2014, Chicago, Illinois
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b61c8e02fa3c0992bd2459f01cf0cc817a4d206e6b1bdba2693ba7a717108a15272ede296bc4beb2bdf0d42a3c4a128d6b3ac0a3320c590f8c19a73f0afe20c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/200264/cdc_200264_DS1.pdf
• File Type:
  [PDF - 69.46 KB ]