Decline in the prevalence of airflow limitation in US adults aged 40-79: NHANES, 1988-1994 and 2007-2010

Details

• Personal Author:
  Dillon C ; Doney B ; Hnizdo, Eva ; Paulose-Ram R ; Tilert T ; Wolz M
• Description:
  Rationale: The objective of this study was to investigate changes in the prevalence of airflow limitation for the US adult population between 1988-1994 and 2007-2010. Methods: Spirometry data from the National Health and Nutrition Examination Surveys, nationally representative surveys of the non-institutionalized US population, conducted during 1988-1994 and 2007-2010 were analyzed. The prevalence of airflow limitation was estimated in adults aged 40-79 using pre-bronchodilator spirometry test results based on criteria from the American Thoracic Society (ATS) and a modification of the Global Initiative for Obstructive Lung Disease (GOLD) criteria. Airflow limitation was defined as forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) < lower limit of normal (LLN) (ATS) and as FEV1/FVC < 70% (GOLD), respectively. Cut points for moderate or worse airflow limitation were defined as FEV1/FVC < LLN plus FEV1 < 70% predicted (ATS) or FEV1 /FVC < 70% plus FEV1 < 80% predicted (GOLD). Results: Based on ATS criteria, the overall age-adjusted prevalence of airflow limitation among adults 40-79 years decreased from 19.8% (SE 0.9) in 1988-1994 to 14.5% (SE 0.7) in 2007-2010 (p<0.01). Significant decreases between the two survey periods were seen for those aged 60-69 years (24.4% vs. 15.4%; p<0.01), 70-79 years (24.4% vs. 17.2%; p<0.05), for men (22.6% vs. 15.3%; p<0.01) and women (17.5% vs. 13.8%; p<0.05), and for non-Hispanic white adults (21.2% vs. 15.8%; p<0.01). Using the modified GOLD criteria, the overall age-adjusted prevalence of airflow limitation decreased from 22.1% (SE 0.7) to 19.9% (SE 1.0) (p<0.05). Significant decreases between the two survey periods were only seen among men (27.6% vs. 23.9%; p<0.05) and Mexican-American adults (15.1% vs. 10.3%; p<0.05). The prevalence of moderate or worse airflow limitation decreased from 7.2% (SE 0.5) to 4.3% (SE 0.4) (p<0.01) based on the ATS criteria and from 11.7% (SE 0.5) to 9.0% (SE 0.6) (p<0.01) based on the modified GOLD criteria. During 2007-2010, an estimated 5.4 million adults aged 40-79 years had moderate or worse airflow limitation based on the ATS criteria. Conclusions: The overall prevalence of airflow limitation in US adults decreased from 1988-1994 to 2007-2010 based on both the ATS and modified GOLD criteria. Significant declines in the prevalence of airflow limitation for the various age, gender, and race-ethnic groups varied by the criteria used to define airflow limitation. [Description provided by NIOSH]
• Subjects:
  Aging Lung Diseases Men Occupational Health Race Factors Respiratory Function Tests Respiratory Tract Diseases Safety Surveys And Questionnaires Women
• Keywords:
  Age-groups Airway-obstruction Health-surveys Humans Lung-disease Pulmonary-function-tests Pulmonary-system-disorders Racial-factors Respiratory-system-disorders Spirometry Surveillance-programs Vital-capacity

  More +
• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  187
• NIOSHTIC Number:
  nn:20044513
• Citation:
  Am J Respir Crit Care Med 2013 May; 187(Meeting Abstracts):A3642
• Contact Point Address:
  B. Doney, National Institute for Occupational Safety and Health, Morgantown, WV
• Email:
  bdoney@cdc.gov
• Federal Fiscal Year:
  2013
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Meeting Abstracts
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2460db533d3429d1276a5680729cc9fa776b99c961d3bfe625ae402d3a50baa2b1cce7196267eea254ae275df305266bea8f748436f53dd58844c82469edab38
• Download URL:
  https://stacks.cdc.gov/view/cdc/200199/cdc_200199_DS1.pdf
• File Type:
  [PDF - 18.95 KB ]