Peripheral nerve function and lower extremity muscle power in older men

Details

• Personal Author:
  Boudreau RM ; Caserotti P ; Cauley JA ; Cawthon PM ; Faulkner K ; Goodpaster BH ; Lee C ; Newman AB ; Strotmeyer ES ; Ward RE ; Zivkovic S
• Description:
  Objective: To assess whether sensorimotor peripheral nerve function is associated with muscle power in community-dwelling older men. Design: Longitudinal cohort study with 2.3+0.3 years of follow-up. Setting: One clinical site. Participants: Participants (n=372; mean age + SD, 77.2 + 5.1y; 99.5% white; body mass index, 27.9=3.7kg/m2; power, 1.88+0.6W/kg) at 1 site of the Osteoporotic Fractures in Men Study (N=5994). Interventions: Not applicable. Main Outcome Measures: A nerve function ancillary study was performed 4.6+0.4 years after baseline. Muscle power was measured using a power rig. Peronealmotor nerve conduction amplitude, distal motor latency, andmean f-wave latency were measured. Sensory nerve functionwas assessed using 10-g and 1.4-g monofilaments and sural sensory nerve conduction amplitude and distal latency. Peripheral neuropathy symptoms at the leg and feet were assessed by self-report. Results: After adjustments for age, height, and total body lean and fat mass, 1 SD lower motor (B=-.07, P<.05) and sensory amplitude (B>09, P<.05) and 1.4-g (B=-.11, P<.05) and 10-g monofilament insensitivity (B=-17, P<.05) were associated with lower muscle power/kg. Compared with the effect of age on muscle power (B per year, -.05; P<.001), this was equivalent to aging 1.4 years for motor amplitude, 1.8 years for sensory amplitude, 2.2 years for 1.4-g monofilament detection, and 3.4 years for 10-g detection. Baseline 1.4-g monofilament detection predicted a greater decline in muscle power/kg. Short-term change in nerve function was not associated with concurrent short-term change in muscle power/kg. Conclusions: Worse sensory and motor nerve function were associated with lower muscle power/kg and are likely important for impaired muscle function in older men. Monofilament sensitivity was associated with a greater decline in muscle power/kg, and screening may identify an early risk for muscle function decline in late life, which has implications for disability. [Description provided by NIOSH]
• Subjects:
  Accidental Falls Accidents Aging Men Musculoskeletal System Occupational Health Safety Sense Organs Women
• Keywords:
  Age-groups Author Keywords: Aged Fall-protection Force Humans Motor Neurons Muscles Muscle Weakness Nerve-function Peripheral Nerves Physical-reactions Physiological-effects Physiological-factors Physiological-function Physiology Rehabilitation Sensory-motor-system Sensory Function Sensory Neurons

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• ISSN:
  0003-9993
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Florida ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 9 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  NPPTL - National Personal Protective Technology Laboratory
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  95
• Issue:
  4
• NIOSHTIC Number:
  nn:20044355
• Citation:
  Arch Phys Med Rehabil 2014 Apr; 95(4):726-733
• Contact Point Address:
  Elsa S. Strotmeyer, PhD, MPH, University of Pittsburgh, Dept of Epidemiology, 130 N Bellefield Ave, Rm 515, Pittsburgh, PA 15213
• Email:
  StrotmeyerE@edc.pitt.edu
• Federal Fiscal Year:
  2014
• Peer Reviewed:
  True
• Source Full Name:
  Archives of Physical Medicine and Rehabilitation
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4fd9c9cb7622300d0ddeaa4ea535793199227a094d556e270e1790212af6a851aa2e907c80201a0b9cf40ff773e586c8775c52ff794d4cd0fdd5396be562477a
• Download URL:
  https://stacks.cdc.gov/view/cdc/200072/cdc_200072_DS1.pdf
• File Type:
  [PDF - 358.35 KB ]