Application of QSAR models to evaluate the dermal absorption of cosmetic ingredients

Details

• Personal Author:
  Frasch H ; Frederick DM ; Liu F ; Tu V
• Description:
  Systemic exposure to cosmetic ingredients is an important factor to take into account during human health safety evaluation of cosmetic products. The information on dermal absorption is critical in order to accurately evaluate the systemic exposure. In vitro methods have been widely applied to determine the dermal absorption of cosmetic ingredients. Also, QSAR models have been proposed and utilized to predict the dermal absorption of chemicals based on their chemical properties. To evaluate the performance of various QSAR models to predict the dermal absorption of cosmetic ingredients, an in vitro dermal absorption study was conducted using a porcine (pig) skin model. Diglycerin is a common humectant used in cosmetic products and was used as a model ingredient in the current study. The dermal absorption profile over a 24-hour exposure period was measured and the kinetic data were fitted to various diffusion models and a combined diffusion/ binding model. The permeability coefficient (Kp) and lag time (t) were estimated with these models. The Kp value was compared with those predicted from publically available QSARs models. The maximum flux values (Jmax) were calculated from the kp values. Based on the Jmax values, default % dose absorbed (Kroes et al., 2007) through the skin per 24 hours ranged from 40% to 80%. The dermal absorption determined from the actual data is generally in agreement with the QSAR model prediction. The current study supports the use of QSAR models to predict dermal absorption for safety assessment of cosmetic ingredients. We suggest that multiple prediction models for dermal absorption should be applied in the absence of experimental data and that the most conservative prediction should be used in systemic exposure assessment of cosmetic ingredients. [Description provided by NIOSH]
• Subjects:
  Chemistry Cosmetics Occupational Health Safety Skin Skin Absorption Toxicology
• Keywords:
  Chemical-composition Chemical-properties Cosmetics-industry Cosmetics-workers Exposure-levels In-vitro-studies In-vitro-study Models Skin-absorption Skin-exposure
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  138
• Issue:
  1
• NIOSHTIC Number:
  nn:20043931
• Citation:
  Toxicologist 2014 Mar; 138(1):414
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing ; Services
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 53rd Annual Meeting and ToxExpo, March 23-27, 2014, Phonex, Arizona
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:94a06a3728f6e80c9c16d28d300aa3be995d6ab5503ed4fdcc56b71fcd695a96358f2d2cdff9d951aec57259203c7dc6a9a2e2028e843583a18b4e87c5bec9c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/199798/cdc_199798_DS1.pdf
• File Type:
  [PDF - 236.62 KB ]