Temporal changes in rat liver gene expression after cadmium and chromium exposure

Details

• Personal Author:
  Baer CE ; Dennis WE ; Jackson, David A. ; Leonard, Stephen S. ; Lewis JA ; Madejczyk MS ; Minarchick VC ; Stallings JD
• Description:
  Our Nation's Guardians are at risk of exposure to a variety of environmental health hazards throughout their normal duty activities including deployments, training exercises, and homeland defense situations. Metals are widely used in large quantities in a number of industrial processes and are common environmental toxicants, which increases the possibility of our Soldiers being exposed at toxic levels. While metal toxicity has been widely studied, the exact mechanisms of toxicity remain unclear. In order to further elucidate these mechanisms and identify candidate biomarkers, rats were exposed via a single intraperitoneal injection to three concentrations of CdCl2, NiCl2 and Na2Cr2O7, and livers were harvested 1, 3, or 7 days after exposure. Cd and Cr accumulated in the liver at 1 day post-exposure, while there was no accumulation of Ni. Cd levels remained elevated over the length of the experiment, while Cr levels declined. Differentially expressed genes were identified via microarray analysis. Both common and uniquely modulated transcripts and perturbed pathways were identified for the metal species. Enriched pathways and functions included hepatic injury, inflammation, cell cycle, tissue repair, and cancer. This work provides insight into the temporal effects and mechanistic pathways involved in acute metal intoxication, which may lead to the identification of candidate biomarkers. [Description provided by NIOSH]
• Subjects:
  Animals Biomarkers Chemistry Environmental Exposure Environmental Health Environmental Pollution Hazardous Substances Laboratories Men Metals Occupational Health Safety Toxicology Women Workplace

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• Keywords:
  Chemical-composition Environmental-exposure Environmental-hazards Environmental-health Exposure-levels Humans Laboratory-animals Metal-compounds Metallic-compounds Soldiers Toxins Work-environment Workers

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  138
• Issue:
  1
• NIOSHTIC Number:
  nn:20043923
• Citation:
  Toxicologist 2014 Mar; 138(1):344
• CAS Registry Number:
  Cadmium (CAS RN 7440-43-9) ; Cadmium chloride (CAS RN 10108-64-2) ; Chromium (CAS RN 7440-47-3) ; Nickel (CAS RN 7440-02-0) ; Nickel dichloride (CAS RN 7718-54-9) ; Sodium dichromate (CAS RN 10588-01-9)
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 53rd Annual Meeting and ToxExpo, March 23-27, 2014, Phonex, Arizona
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7dfb8b9fbc0aa5f06149b9954c93e53516a13ab0a96a40290cc05b0027f5a393f4e2a43e0cbfd978613dc21006cf4de086527349b8b5d0c51a18e3273764f075
• Download URL:
  https://stacks.cdc.gov/view/cdc/199791/cdc_199791_DS1.pdf
• File Type:
  [PDF - 245.37 KB ]