The Effects of Single and Serial Zinc Oxide Exposures on Airway Inflamation in Healthy Humans

Details

• Personal Author:
  Arjomandi M ; Balmes J ; Blanc, Paul ; Reinties K ; Solomon C ; Witten A
• Description:
  A single exposure to zinc oxide (ZnO) results in an increase in inflammatory cells and cytokines. Serial exposures to ZnO can decrease this inflammatory response. This experiment was designed to test the hypothesis that exposure to ZnO on two consecutive occasions would decrease both the cellular and cytokine responses compared 10 one exposure. Utilizing a repeated measure, randomized, single-blind design, 6 healthy subjects (4 females; age range 26-53 yr; methacholine PC,. > 10 mg/ml) were exposed for 30 min, at rest, to: I) filtered-air (FA); 2) ZnO on one occasion (ZnO-I: conc: 10 mg/ m'); 3) ZnO on two consecutive occasions (ZnO-2: conc: 10 mg/m'). Sputum induction (3% saline, t=20 min) was performed 65 h pre- and 6 h post-exposure, Conditions were compared using the post minus pre delta value. In ZnO-I, compared to FA, there was a significant (P
• Subjects:
  Filtration Occupational Health Safety Zinc Compounds
• Keywords:
  Exposure-levels Exposure-limits Filters Leukocytes Proteins Sputum-analysis Sputum-cytology Zinc-compounds
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  165
• Issue:
  8
• NIOSHTIC Number:
  nn:20022922
• Citation:
  Am J Respir Crit Care Med 2002 Apr; 165(8)(Suppl):A46
• CAS Registry Number:
  Zinc oxide (ZnO) (CAS RN 1314-13-2)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  Center for Occupational and Enviromental Health, University of California, Berkley California
• Peer Reviewed:
  False
• Start Date:
  19940701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine, 2002 International Conference, The American Thoracic Society, Atlanta Georgia, May 17-22, 2002
• Supplement:
  Suppl
• End Date:
  20060630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4bdb3629e37da50756940645e9b6c264bc4b39f40719ef6d57e38708003e367a657c95dacc08e0f89bf606e90f71ef15fcf2e1fb606a19f97d39cff0bed40238
• Download URL:
  https://stacks.cdc.gov/view/cdc/199535/cdc_199535_DS1.pdf
• File Type:
  [PDF - 274.64 KB ]