Occupational Silica Exposure and Risk of Various Diseases: An Analysis Using Death Certificates from 27 States of the United States

Details

• Personal Author:
  Boiano, James M. ; Calvert, Geoffrey M. ; Rice, Faye L. ; Sanderson, Wayne T. ; Sheehy, John W.
• Description:
  Although crystalline silica exposure is associated with silicosis, lung cancer, pulmonary tuberculosis, and chronic obstructive pulmonary disease (COPD), there is less support for an association with autoimmune disease, and renal disease. Using data from the US National Occupational Mortality Surveillance (NOMS) system, a matched case-control design was employed to examine each of several diseases (including silicosis, lung cancer, stomach cancer, oesophageal cancer, COPD, pulmonary tuberculosis, sarcoidosis, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and various types of renal disease). Cases were subjects whose death certificate mentioned the disease of interest. A separate control group for each of the diseases of interest was selected from among subjects whose death certificate did not mention the disease of interest or any of several diseases reported to be associated with crystalline silica exposure. Subjects were assigned into a qualitative crystalline silica exposure category based on the industry/occupation pairing found on their death certificate. We also investigated whether silicotics had a higher risk of disease compared to those without silicosis. Those postulated to have had detectable crystalline silica exposure had a significantly increased risk for silicosis, COPD, pulmonary tuberculosis, and rheumatoid arthritis. In addition, a significant trend of increasing risk with increasing silica exposure was observed for these same conditions and for lung cancer. Those postulated to have had the greatest crystalline silica exposure had a significantly increased risk for silicosis, lung cancer, COPD, and pulmonary tuberculosis only. Finally, those with silicosis had a significantly increased risk for COPD, pulmonary tuberculosis, and rheumatoid arthritis. This study corroborates the association between crystalline silica exposure and silicosis, lung cancer, COPD, and pulmonary tuberculosis. In addition, support is provided for an association between crystalline silica exposure and rheumatoid arthritis. [Description provided by NIOSH]
• Subjects:
  Dust Kidney Diseases Lung Lung Diseases Mortality Neoplasms Occupational Exposure Occupational Health Quartz Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide Urogenital Diseases Urogenital System

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• Keywords:
  Autoimmunity Chronic-exposure Kidney-disorders Lung-cancer Mortality-data National Occupational Mortality Surveillance NOMS Pulmonary-system-disorders Quartz-dust Renal-toxicity Respiratory-system-disorders Rheumatoid-disorders Silica-dusts Silicosis Surveillance-programs

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; DART - Division of Applied Research and Technology ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  122-129
• Volume:
  60
• Issue:
  2
• NIOSHTIC Number:
  nn:20022432
• Citation:
  Occup Environ Med 2003 Feb; 60(2):122-129
• Contact Point Address:
  National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-21, Cincinnati, OH 45226, USA
• Email:
  JAC6@CDC.GOV
• CAS Registry Number:
  Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2003
• NORA Priority Area:
  Research Tools and Approaches: Control Technology and Personal Protective Equipment
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20060930
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a8c2a3449070906f8c80d5b8be6b9d62a4ecf8c201bacd2e2849927c198e88250b1f66d91b6b9b86c2f7d909a1434be75a340541a39f7e714c1953561b7fc84e
• Download URL:
  https://stacks.cdc.gov/view/cdc/199215/cdc_199215_DS1.pdf
• File Type:
  [PDF - 214.47 KB ]