Development of Quantitative Exposure Data for a Pooled Exposure-Response Analysis of 10 Silica Cohorts

Details

• Personal Author:
  Attfield, Michael ; Checkoway, Harvey ; Chen J ; DeKlerk N ; Dosemci M ; Hnizdo, Eva ; Koponen M ; Koskela R ; Mannetje A ; Steenland, Kyle
• Description:
  Comprehensive quantitative silica exposure estimates over time, measured in the same units across a number of cohorts, would make possible a pooled exposure-response analysis for lung cancer. Such an analysis would help clarify the continuing controversy regarding whether silica causes lung cancer. Existing quantitative exposure data for 10 silica-exposed cohorts were retrieved from the original investigators. Occupation- and time-specific exposure estimates were either adopted/adapted or developed for each cohort, and converted to milligram per cubic meter (mg/m(3)) respirable crystalline silica. Quantitative exposure assignments were typically based on a large number (thousands) of raw measurements, or otherwise consisted of exposure estimates by experts (for two cohorts). Median exposure level of the cohorts ranged between 0.04 and 0.59 mg/m(3) respirable crystalline silica. Exposure estimates were partially validated via their successful prediction of silicosis in these cohorts. Existing data were successfully adopted or modified to create comparable quantitative exposure estimates over time for 10 silica-exposed cohorts, permitting a pooled exposure-response analysis. The difficulties encountered in deriving common exposure estimates across cohorts are discussed. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Dust Lung Lung Diseases Minerals Mining Neoplasms Occupational Health Quartz Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide

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• Keywords:
  Author Keywords: Crystalline Silica Cancer-rates Cohorts Diatomaceous Earth Exposure-levels Granite Industrial Sand Lung-cancer Lung-disease Metal Mines Mine-workers Mineral-processing Pottery Quantitative-analysis Quantitative Exposure Estimates Quartz-dust Silica-dusts Silicates

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 5 ; OSHA Region 8 ; OSHA Region 9 ; South Dakota ; Vermont ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  73-86
• Volume:
  42
• Issue:
  2
• NIOSHTIC Number:
  nn:20022283
• Citation:
  Am J Ind Med 2002 Aug; 42(2):73-86
• Contact Point Address:
  Kyle Steenland, NIOSH R13, DHHS, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226
• Email:
  kns1@cdc.gov
• CAS Registry Number:
  Diatomite (CAS RN 61790-53-2) ; Quartz (SiO2) (CAS RN 14808-60-7)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19940401
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  19960331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:49d8b39a153f978637d1b41c391612b20c190dff897a772d2e294506cc3eb469804c7f647f2564fb27dc27c3d438879ea08137fd61fb0383f10d79d201e125c7
• Download URL:
  https://stacks.cdc.gov/view/cdc/199106/cdc_199106_DS1.pdf
• File Type:
  [PDF - 136.50 KB ]