Immunotoxicology of Organic Acid Anhydrides (OAAs)

Details

• Personal Author:
  Lewis, Daniel M. ; Siegel, Paul D. ; Zhang XD
• Description:
  Organic acid anhydrides (OAAs) have considerable economic importance due to their extensive use in the production of alkyd, epoxy, and polyester resins. Occupational exposure to OAAs has been associated with a variety of health effects, which may be classified into two major categories of direct toxicity/irritant and hypersensitivity. The hypersensitivity diseases associated with OAA exposure are thought to be related to the reactivity of these chemicals and in particular their ability to form protein conjugates that may be recognized as neo-antigens by the immune system. This review will present a brief discussion of the basic chemistry of these compounds and the environmental and biological monitoring methods used for exposure measurements. The clinical syndromes associated with exposure to these compounds will be discussed along with factors that may affect disease susceptibility. Finally, animal models that have been developed to examine the mechanisms of disease will be discussed. [Description provided by NIOSH]
• Subjects:
  Anhydrides Animals Antibodies Asthma, Occupational Epoxy Resins Hazardous Substances Hypersensitivity Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Allergic-disorders Alveolar-cells Animal-studies Animal Models Antibody-response Author Keywords: Organic Acid Anhydrides Epoxy-resins Immune-system Immunotoxins Lung-disease Occupational-respiratory-disease Occupational Asthma Occupational Lung Disease Organic-acids Proteins Pulmonary-system-disorders Respiratory-system-disorders Toxic-effects

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• ISSN:
  1567-5769
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  239-248
• Volume:
  2
• Issue:
  2
• NIOSHTIC Number:
  nn:20022204
• Citation:
  Int Immunopharmacol 2002 Feb; 2(2-3):239-248
• Contact Point Address:
  Analytical Services Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
• CAS Registry Number:
  Maleic anhydride (CAS RN 108-31-6) ; Phthalic anhydride (CAS RN 85-44-9) ; Trimellitic anhydride (CAS RN 552-30-7)
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  International Immunopharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:946958ef51584556b7ca6c30b6b7eb786e5826b7cf9692ba2d366806b40be8c2483ddfcd975b77493e72cae564c8cffff7d1bbdc5782efe6b79b940ed954c2a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/199066/cdc_199066_DS1.pdf
• File Type:
  [PDF - 143.67 KB ]